| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | Targeting the activation of Stat3 may be a potential therapeutic approach for EOC by acting synergistically with paclitaxel. | 31778258 | 2020 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Phosphorylation of T372 by PKA enhanced the interaction between EZH2 and signal transducer and activator of transcription 3 (STAT3), and STAT3 binding to pT372-EZH2 reduced cellular levels of pSTAT3 and downregulated interleukin 6 receptor expression in OC. | 29576612 | 2018 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | In this study, we tested our hypothesis that STAT3 regulates MMP-9 gene expression in epithelial ovarian cancer. | 28859117 | 2017 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | These results suggest that NANOG mediates EMT and drug resistance through activation of the Stat3 pathway in epithelial ovarian cancer. | 26801672 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | Here, we show epithelial ovarian cancer (EOC)-derived exosomes activated macrophages to a tumor-associated macrophage (TAM)-like phenotype with SOCS3/STAT3 pathway involvement, which could facilitate the progression of cancer. | 27172798 | 2016 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | This is the first study to identify germline STAT3 variants as independent predictors of an unfavorable therapeutic response for EOC patients. | 26264211 | 2016 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Moreover, the ascites treatment induced the phosphorylation of JAK2-STAT3 and use of selective inhibitors of JAK2 and STAT3, blocked the expression of epithelial-mesenchymal transition related proteins in parallel with the suppression of EOC invasion. | 27825119 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | The STAT3 pathway responded early to platinum drugs associated with cisplatin resistance in epithelial ovarian cancer and provided a rationale for new therapeutic strategies to reverse cisplatin resistance. | 23969971 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo. | 23828376 | 2013 |