Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASCAT Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. 28604730 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease BEFREE We did not identify increased frequencies of oesophageal, pancreatic or lung cancer in families with just BRCA2 c.9976A>T using person-years at risk analysis. 26041759 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 Biomarker disease BEFREE Antisense-mediated reduction of IDO, alone and (in a synthetic lethal approach) in combination with antisense to the DNA repair protein BRCA2 sensitizes human lung cancer cells to olaparib and cisplatin. 24784564 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease BEFREE Our results show that LUDLU-1 lacks the mutational signature that has been previously associated with tobacco exposure in other lung cancer subtypes, and suggests that DNA-repair efficiency is adversely affected; LUDLU-1 contains somatic mutations in TP53 and BRCA2, allelic imbalance in the expression of two cancer-associated BRCA1 germline polymorphisms and reduced transcription of a potentially endogenous PARP2 inhibitor. 24244370 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASCAT Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASDB We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease BEFREE Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASCAT We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease GWASDB Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GeneticVariation disease BEFREE Association of allelic imbalance at locus D13S171 (BRCA2) and p53 alterations with tumor kinetics and chromosomal instability (aneuploidy) in nonsmall cell lung carcinoma. 11064350 2000
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 CausalMutation disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.450 GenomicAlterations disease CGI