However; in subgroup analyses by cancer type, a significant association between EXO1Glu589Lys and lung cancer risk was found (Lys vs Glu: OR=1.23, 95%CI=1.07- 1.41, p heterogeneity=0.05).
Our results provide the first evidence that the A allele of Exo1K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
These results suggest that the EXO1Glu589Lys polymorphism and its surrounding regions might be genetic susceptibility markers for lung cancer in this study population.