×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
COX2 -1195G > A polymorphism may serve as a genetic biomarker of gastric cancer in both Asians and Caucasians.30391440 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Finally, we demonstrated that combinatorial inhibition of COX-2 and DNMT using Celecoxib and Decitabine synergistically inhibited GC growth <i>in vitro</i> and <i>in vivo</i>.
31534549 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
COX-2 and MMP-13 can be used as reference indexes to guide the treatment of gastric cancer and predict the disease prognosis.30003735 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
COX-2 and MMP-13 can be used as reference indexes to guide the treatment of gastric cancer and predict the disease prognosis.30941969 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
EBV down-regulates COX-2 expression via TRAF2 and ERK signal pathway in EBV-associated gastric cancer .
31473273 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
PosttranslationalModification
disease
BEFREE
This work aimed to study COX-2 methylation and expression in N-methyl-N-Nitrosurea (MNU)-induced intestinal GC in six Sapajus apella animals.
29767663 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Combined administration of γ-secretase and COX-2 inhibitor produced a marked inhibition of growth in AGS cells, which suggests that patients with poorly differentiated GC may benefit from the blockage of NICD, which potentially serves a role in GC differentiation.
29616098 2018
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2 /PGE2-PI3K/AKT/GSK3<i>β</i>/<i>β</i>-Catenin Signaling Pathway.
29358963 2017
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
In 180 cases of GC , the clinicopathologic features were correlated with the results obtained after paired immunohistochemical stains (tumor/normal mucosa) with 15 antibodies: E-cadherin, HER-2, VEGF, CD31, CD105, COX-2 , maspin, bax, bcl-2, p53, Ki67, MLH-1, MSH-2, Mena protein, and vimentin.
26067133 2017
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- κB Signaling Pathways.
29151957 2017
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Inflammation in gastric cancer : Interplay of the COX-2 /prostaglandin E2 and Toll-like receptor/MyD88 pathways.
27079437 2016
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
Moreover, the overexpression of transcription factor C/EBPβ in gastric cancer interacted with NFκB and further regulates COX-2 expression.
26514342 2016
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
GeneticVariation
disease
BEFREE
In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer .
27352184 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
PosttranslationalModification
disease
BEFREE
No significant association was found between COX-2 methylation and risk of GC (OR, 1.15; 95% CI: 0.70-1.88).
26674784 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
PosttranslationalModification
disease
BEFREE
Therefore, our results suggest that the methylation status of the gene COX2 is associated with the intestinal type of gastric cancer .
24014049 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
We confirm loss of ANXA1 and overexpression of COX-2 in clinical gastric cancer , suggesting that the anti-proliferative function of ANXA1 against COX-2 production might be lost.
25038797 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
The mechanism as to how COX2 is regulated during the gastric cancer development is largely unknown.
24308961 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
COX-2 is expressed in DCAMKL1-expressing quiescent tuft cells in gastric carcinoma .25228975 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
GeneticVariation
disease
BEFREE
Among the Chinese Hui ethnic group COX-2 -765 C allele carriers were at increased risk for gastric cancer (OR=1.977, 95%CI=1.104-3.541).
24935598 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
The role of anti-LeY antibody in the downregulation of MAPKs/COX-2 pathway in gastric cancer .
24533777 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
Together, these findings provide new evidence for a positive feedback loop between STAT3 signaling and COX-2 in H. pylori pathogenesis and may lead to new approaches for early detection and effective therapy of gastric cancer
24127267 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
COX-2 regulates E-cadherin expression through the NF-κB/Snail signaling pathway in gastric cancer .23670240 2013
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
Notch2-induced COX-2 expression enhancing gastric cancer progression.
21976141 2012
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
AlteredExpression
disease
BEFREE
COX-2 is overexpressed in various cancers, including gastric cancer .22385256 2012
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100
Biomarker
disease
BEFREE
COX-2 might mediate tumor angiogenesis and growth, and could be considered as a target for gastric cancer therapy.21266034 2011