×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
CausalMutation
disease
CGI
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest.
19955487
2010
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR (qPCR) and western blotting, and miR-100 by qPCR.
23778527
2013
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder .
14678961
2003
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer .
16061860
2005
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer .
17668422
2007
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
FGFR3 analyses did not reveal any mutation in the urothelium from neither the control group nor the bladder cancer group.
19621447
2009
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
FGFR3 mutational status and protein expression in patients with bladder cancer in a Jordanian population.
20542753
2010
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
FGFR3 overexpression is prognostic of adverse outcome for muscle-invasive bladder carcinoma treated with adjuvant chemotherapy.
24360661
2014
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
FGFR3 translocations in bladder cancer : differential sensitivity to HSP90 inhibition based on drug metabolism.
24784839
2014
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
FGFR3 mutations are common in low-grade BC , while TP53 mutation or loss of RB1 is associated with muscle-invasive BC .
26924873
2016
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
Fibroblast growth factor receptor 3 (FGFR3 ) is an actionable target in bladder cancer .
27091807
2016
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
FGFR3 -TACC3 fusion transcripts were identified by RNA-FISH and RT-PCR in mouse xenograft FFPE tissues using the human BC cell lines RT112 and RT4.
27930669
2016
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
FGFR3 , TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
28049011
2017
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine.
16278395
2005
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
Activating mutations of FGFR3 are a common and early event in bladder cancer .
25223521
2015
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
Activating point mutations and protein overexpression of fibroblast growth factor receptors (FGFRs), especially FGFR3 , are frequent events in bladder cancer .
24898159
2015
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
An example of a TM domain pathogenic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3 ), linked to Crouzon syndrome with acanthosis nigricans, as well as to bladder cancer .
16384584
2006
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
Analysing only previously reported point mutations, TERT mutations were found in 55% of patients with bladder cancer (independent of stage), FGFR3 mutations in 30% of patients with bladder cancer , PIK3CA in 14% and TP53 mutations in 12% of patients with bladder cancer.
26901314
2016
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
CLINVAR
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
19381019
2009
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
Antitumor activity of fibroblast growth factor receptor 3 -specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis.
18413799
2008
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
Biomarker
disease
BEFREE
As for FGFR3 in UCC , tumors with high FOXA1 expression have lower rates of progression than those with low expression (Log rank p=0.009).
25071007
2014
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
BEFREE
CDKN2A homozygous deletion is associated with muscle invasion in FGFR3 -mutated urothelial bladder carcinoma .
22422578
2012
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
AlteredExpression
disease
BEFREE
Conversely, FGFR3 over-expression was recently found in 40 % of muscle invasive BC .
24880661
2014
×
Entrez Id:
2261
Gene Symbol:
FGFR3
FGFR3
0.500
GeneticVariation
disease
CLINVAR
FGFR3 mutational status and protein expression in patients with bladder cancer in a Jordanian population.
20542753
2010