|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the demonstration that p73 is monoallelically expressed supports the notion that it is a candidate gene in neuroblastoma. p73 also has the potential to activate p53 target genes and to interact with p53.
|
9288759 |
1997 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, p73 was expressed at higher levels in the CRC tissues than in the normal mucosa or neuroblastoma tissues, though the transcripts were detectable only by the RT-PCR method.
|
9664127 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its location on human chromosome 1p36.33 implicates p73 as a candidate for neuroblastoma.
|
9721206 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our data argue that p73 is unlikely to be a suppressor gene inactivated during neuroblastoma development.
|
9831242 |
1998 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.
|
10023682 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The p73 gene is monoallelically expressed in normal tissue, maps to chromosome 1p36 and is deleted in human neuroblastoma cell lines.
|
10213163 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we could find no evidence for p73 being the neuroblastoma tumor suppressor gene in 1p36.
|
10341287 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel p73 gene, which is related to p53, has recently been identified and mapped to chromosome 1p36.3, which is a locus of multiple tumour-suppressor genes for many cancers, including hepatocellular carcinoma (HCC) and neuroblastoma.
|
10408709 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.
|
10601564 |
2000 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the p73 gene is less involved in the development but involved in the progression of neuroblastoma.
|
10719054 |
2000 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
The p63 and p73 genes are rarely mutated in human cancer, although p73 loss is observed in neuroblastoma and a subtype of T-cell lymphoma. p53, p63 and p73 appear to have overlapping and distinct functions: p53 regulates the stress response to suppress tumors; p63 is essential for ectoderm development; and p73 might regulate both the stress response and development.
|
10769197 |
2000 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sequence analysis of the p73 coding region in the mRNAs expressed by these cell lines and tumors did not reveal inactivating mutations, suggesting that p73 is not homozygously inactivated in neuroblastoma.
|
10935473 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Alteration of the p53 tumor suppressor gene is a common, if not general, observation in human malignant tumors. p73 Is a novel member of the p53 family at chromosome 1p36.3, at which locus frequent defects are seen in many tumors including neuroblastoma.
|
10972855 |
2000 |
|
ARHGAP24
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
We concluded that it is unlikely that p73 is imprinted in neuroblastoma and that the methylation-dependent silencing of this gene, thus far, is a characteristic of hematologic malignancies.Oncogene (2000) 19, 4553 - 4556.
|
11002429 |
2000 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results are supportive of a role for p73 in the biology of neuroblastoma, particularly in some advanced tumors.
|
11205839 |
2001 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although p73 is infrequently mutated in human cancers, we have previously found two types of p73 mutation with amino acid substitution (P405R and P425L) in primary neuroblastoma and lung cancer.
|
11429704 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although p73 maps at 1p36.3 and is frequently deleted in neuroblastoma (NB), it does not act as a classic oncosuppressor gene.
|
11859407 |
2002 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The N-myc gene was transfected into two neuroblastoma cell lines that lacked N-myc amplification to determine its effect on p73 RNA levels. p73 was detectable at low level by RT-PCR in untransfected SK-N-AS cells and became undetectable following N-myc transfection, whereas in SH-EP1 cells, p73 levels were substantially reduced following transfection but remained detectable.
|
12192602 |
2003 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma.
|
12880969 |
2003 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigates whether there is a functional link between p73 isoforms and p53 in neuroblastoma.
|
14676279 |
2004 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, altered expression of the p73 gene has been reported in neuroblastoma, lung cancer, prostate cancer and renal cell carcinoma.
|
15385938 |
2004 |
|
ARHGAP24
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients.
|
15650242 |
2004 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The p53 gene and its homologue p73 are rarely mutated in neuroblastoma.
|
15741235 |
2005 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential regulation of p73 variants in response to cisplatin treatment in SH-SY5Y neuroblastoma cells.
|
16773194 |
2006 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Valproic acid diminished N-myc and enhanced p73 protein level, coupled with downregulation of deltaNp73 in UKF-NB-3(VCR) and UKF-NB-3(CDDP).
|
17505515 |
2007 |