Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We observed an increased total iron content in G93A-SOD1 SH-SY5Y neuroblastoma cells compared to wild-type (WT)-SOD1 cells. mRNA expression for transferrin receptor 1 (TfR1) and divalent metal transporter 1 was increased in G93A-SOD1 cells, which was in accordance with higher iron uptake. 23178912 2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE SOD1 misfolding and oxidation was also detected using immunocytochemistry and quantitative immunoprecipitation of human neuroblastoma SH-SY5Y cells as well as cultured murine spinal neural cells transgenic for human wtSOD1, which were transiently transfected with human cytosolic mutant FUS or TDP43, or wtTDP43. 22493728 2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Overexpression of a familial mutant form of superoxide dismutase 1 (SOD1) (G93A) in neuroblastoma cells resulted in a similar reduction of IGF-1Rβ protein. 22875931 2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We also detected oligomer formation of L84V SOD1 in L84V SOD1-expressing human neuroblastoma cells. 20816908 2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat, a neurotoxic herbicide that induces the formation of reactive oxygen species and causes mitochondrial damage in animal models, and SH-SY5Y cells stably expressing the mutant G93A-SOD1 protein, one of the genetic causes of ALS. 21120952 2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Impairment of nuclear factor-kappaB activation increased glutamate excitotoxicity in a motoneuron-neuroblastoma hybrid cell line expressing mutant (G93A) Cu/Zn-superoxide dismutase. 20623531 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE Therefore, the aim of the present study was to examine in the human neuroblastoma SH-SY5Y cell line the impact of a typical (haloperidol) and an atypical (quetiapine) antipsychotic on the expression of genes encoding the key enzymes of the antioxidant metabolism (Cu, Zn superoxide dismutase; Mn superoxide dismutase; glutathione peroxidase; catalase) and enzymes of the glutathione metabolism (gamma-glutamyl cysteine synthetase, glutathione-S-transferase, gamma-glutamyltranspeptidase, glutathione reductase). 19101687 2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Transient cytoskeletal alterations after SOD1 depletion in neuroblastoma cells. 18239850 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury. 17997855 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We detected this interaction both in spinal cord extracts of mutant SOD1(G93A) transgenic mice and in cultured neuroblastoma cells. 17403032 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Previously, we reported that overexpression of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD or SOD2) attenuates cytotoxicity induced by expression of the G37R-SOD1 mutant in a human neuroblastoma cell culture model of ALS. 17394531 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE In order to investigate the basis of the tissue specificity of mutant SOD1 we compared the effect of the continuous expression of wild-type or mutant (G93A) human SOD1 on mitochondrial morphology in the NSC-34 motoneuronal-like, the N18TG2 neuroblastoma and the non-neuronal Madin-Darby Canine Kidney (MDCK) cell lines. 16903849 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE In order to investigate the role of Hsp27 in mutant SOD1-dependent cell death, we used mutant and wild type SOD1 overexpressing N2a mouse neuroblastoma cells. 16806187 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis. 15670639 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change. 15456693 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Activation of caspase-1 and caspase-3 is observed also in neuroblastoma lines expressing other fALS-SOD1s (G37R, G85R, and I113T) cocultured with glioblastoma lines expressing the corresponding mutant enzymes. 15208263 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE We have investigated the functional effects of RNAi-mediated silencing of mutant SOD1 in cultured murine neuroblastoma cells. 14981234 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS. 12753090 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE In this paper, we report a calcineurin-dependent activation of nuclear factor-kappaB (NF-kappaB) induced by the expression of familial amyotrophic lateral sclerosis (fALS)-SOD1s in human neuroblastoma cell lines. 12437573 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We report that the expression of mutant G93A copper/zinc superoxide dismutase (SOD1), associated with familial amyotrophic lateral sclerosis, specifically causes a decrease in MTT reduction rate and ATP levels and an increase in both cytosolic and mitochondrial reactive oxygen species (ROS) production in human neuroblastoma SH-SY5Y cells compared to cells overexpressing wild-type SOD1 and untransfected cells. 12901835 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Expression of mutant SOD1 (G37R) resulted in a time and dose-related death of differentiated neuroblastoma cells. 12067230 2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE It also appears that the Hsp-SOD1 complex recruits other proteins present in the neuroblastoma cell and presumably in motor neurons to form sedimentable aggregates. 12060716 2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE On the contrary, overexpression of mutant SOD1s associated with familial amyotrophic lateral sclerosis (FALS) impairs CN activity both in transfected human neuroblastoma cell lines and in the motor cortex of brain from FALS-transgenic mice. 10899935 2000
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Proteolytic processing characteristic of caspase-1 activation is seen both in spinal cords of transgenic ALS mice and neurally differentiated neuroblastoma (line N2a) cells with SOD1 mutations. 9861044 1999
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We have investigated the response to oxidative stress in a model system obtained by stable transfection of the human neuroblastoma cell line SH-SY5Y with plasmids directing constitutive expression of either wild-type human Cu,Zn superoxide dismutase or a mutant of this enzyme (H46R) associated with familial amyotrophic lateral sclerosis. 10461909 1999