Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE We conclude that human growth hormone treatment of some but not all short children with "normal" growth hormone secretion will result in sustained acceleration of growth rate and attainment of prepubertal heights that are closer to but do not exceed their genetic height potential. 1578304 1992
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Growth velocity was unsatisfactory during growth hormone treatment; a higher dose of growth hormone similar to that used in Ullrich-Turner patients, would probably have improved her growth rate. 8319711 1993
Entrez Id: 3991
Gene Symbol: LIPE
LIPE
0.010 AlteredExpression disease BEFREE Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. 10910003 2000
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.010 AlteredExpression disease BEFREE Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. 10910003 2000
Entrez Id: 6023
Gene Symbol: RMRP
RMRP
0.020 Biomarker disease BEFREE Growth hormone treatment in cartilage-hair hypoplasia: effects on growth and the immune system. 14960021 2004
Entrez Id: 2692
Gene Symbol: GHRHR
GHRHR
0.010 GeneticVariation disease BEFREE Phenotypic analysis and growth response to different growth hormone treatment schedules in two siblings with an inactivating mutation in the growth hormone-releasing hormone receptor gene. 15237716 2004
Entrez Id: 1311
Gene Symbol: COMP
COMP
0.010 Biomarker disease BEFREE Cartilage oligomeric matrix protein increases in serum after the start of growth hormone treatment in prepubertal children. 15472220 2004
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Growth hormone treatment in non-growth hormone-deficient short children. 15887870 2005
Entrez Id: 6023
Gene Symbol: RMRP
RMRP
0.020 Biomarker disease BEFREE An effective case of growth hormone treatment on cartilage-hair hypoplasia. 15780958 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.010 Biomarker disease BEFREE Expression of the antiapoptotic protein bcl-2 was increased in crypt epithelial cells after growth hormone treatment. 16012947 2005
Entrez Id: 2690
Gene Symbol: GHR
GHR
0.020 Biomarker disease BEFREE Because growth hormone receptor alleles were associated with body stature and response to growth hormone treatment, we hypothesized the growth hormone receptor is a candidate predisposing and disease modifier gene for adolescent idiopathic scoliosis. 17514010 2007
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE We report a boy with anhidrotic/hypohidrotic ectodermal dysplasia and growth hormone neurosecretory dysfunction, an association not previously reported, and we discuss the possible causes as well as the patient's response to growth hormone treatment until he reached final height. 19960895 2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.070 Biomarker disease BEFREE Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth-retarded hypokalemic rats: effect of growth hormone treatment. 19587145 2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.070 GeneticVariation disease BEFREE Birth size, postnatal growth and growth during growth hormone treatment in small-for-gestational-age children: associations with IGF1 gene polymorphisms and haplotypes? 19571555 2009
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.010 GeneticVariation disease BEFREE The -202 A allele of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth hormone treatment in patients with severe growth hormone deficiency. 18984657 2009
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy. 19849699 2010
Entrez Id: 2690
Gene Symbol: GHR
GHR
0.020 GeneticVariation disease BEFREE Different relationships between the first 2 years on growth hormone treatment and the d3-growth hormone receptor polymorphism in short small-for-gestational-age (SGA) children. 21623854 2011
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Curves for height/length, weight and body mass index were constructed and compared between Prader-Willi syndrome patients treated with and without growth hormone to determine how growth hormone treatment affected body composition. 22948460 2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.070 GeneticVariation disease BEFREE A pilot study of discontinuous, insulin-like growth factor 1-dosing growth hormone treatment in young children with FGFR3 N540K-mutated hypochondroplasia. 22137367 2012
Entrez Id: 1398
Gene Symbol: CRK
CRK
0.010 Biomarker disease BEFREE The effect of growth hormone treatment in CRK-deficient children is discussed. 22085993 2012
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.010 GeneticVariation disease BEFREE A pilot study of discontinuous, insulin-like growth factor 1-dosing growth hormone treatment in young children with FGFR3 N540K-mutated hypochondroplasia. 22137367 2012
Entrez Id: 6473
Gene Symbol: SHOX
SHOX
0.020 GeneticVariation disease BEFREE Height outcome of the recombinant human growth hormone treatment in patients with SHOX gene haploinsufficiency: a meta-analysis. 23570464 2013
Entrez Id: 7389
Gene Symbol: UROD
UROD
0.010 Biomarker disease BEFREE We evaluated BMD in 79 individuals with the common subtypes of PWS (48 with deletion and 27 with UPD) and the effect of growth hormone treatment (n=46) vs. no growth hormone treatment. 24515997 2014
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 GeneticVariation disease BEFREE SHOX gene variants: growth hormone/insulin-like growth factor-1 status and response to growth hormone treatment. 25659810 2015
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.070 AlteredExpression disease BEFREE Growth hormone treatment is ineffective in most patients with MGS, but may be effective in patients in whom growth continues to decrease after the first year of life (usually growth velocity normalizes after the first year) and with low levels of IGF1. 26381604 2015