Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M 		0.300 Biomarker disease CTD_human Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. 15023809 2004
Entrez Id: 2
Gene Symbol: A2M
A2M 		0.300 Biomarker disease CTD_human Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. 9811940 1998
Entrez Id: 2
Gene Symbol: A2M
A2M 		0.300 Biomarker disease CTD_human Alpha-2 macroglobulin is genetically associated with Alzheimer disease. 9697696 1998
Entrez Id: 20
Gene Symbol: ABCA2
ABCA2 		0.030 GeneticVariation disease BEFREE Recently, a single nucleotide polymorphism (SNP) in Abca2 was linked to early onset Alzheimer's disease (AD). 18348684 2008
Entrez Id: 20
Gene Symbol: ABCA2
ABCA2 		0.030 Biomarker disease BEFREE ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease. 15649702 2005
Entrez Id: 20
Gene Symbol: ABCA2
ABCA2 		0.030 GeneticVariation disease BEFREE Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. 18336955 2009
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		0.320 Biomarker disease CTD_human Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. 21460840 2011
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		0.320 Biomarker disease BEFREE Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer's disease (EOAD). 31381512 2019
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		0.320 GeneticVariation disease BEFREE Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease. 28447221 2017
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		0.320 Biomarker disease CTD_human Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. 25807283 2015
Entrez Id: 51225
Gene Symbol: ABI3
ABI3 		0.300 Biomarker disease CTD_human Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 28714976 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease CTD_human Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. 10643899 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease CTD_human Alzheimer disease risk and genetic variation in ACE: a meta-analysis. 14872014 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease CTD_human Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. 9916793 1999
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.300 Biomarker disease CTD_human Characterisation of acetylcholinesterase release from neuronal cells. 23047022 2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.300 Biomarker disease CTD_human Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β. 22944069 2013
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10 		0.300 Biomarker disease CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047 2019
Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1 		0.300 Biomarker disease CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047 2019
Entrez Id: 8540
Gene Symbol: AGPS
AGPS 		0.010 Biomarker disease BEFREE However, deterioration was significantly faster when using the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) over 3 years in participants with EOAD than in those with LOAD; hence, prediction models for the mean ADAS-Cog trajectories are presented. 28859660 2017
Entrez Id: 267
Gene Symbol: AMFR
AMFR 		0.300 Biomarker disease CTD_human Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. 22313999 2012
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1 		0.010 Biomarker disease BEFREE Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. 15917097 2005
Entrez Id: 322
Gene Symbol: APBB1
APBB1 		0.010 GeneticVariation disease BEFREE A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism. 12727304 2003
Entrez Id: 338
Gene Symbol: APOB
APOB 		0.010 GeneticVariation disease BEFREE Collectively, these novel findings highlight the important role of LDL-C in EOAD pathogenesis and suggest a direct link of APOB variants to AD risk. 31135820 2019