Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Biomarker phenotype CTD_human The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms. 2533336 1989
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker phenotype CTD_human Dopamine D1 and D2 receptors mediate opposite functions in seizures induced by lithium-pilocarpine. 1829682 1991
Entrez Id: 4804
Gene Symbol: NGFR
NGFR 		0.300 Biomarker phenotype CTD_human p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. 10436046 1999
Entrez Id: 6750
Gene Symbol: SST
SST 		0.300 Therapeutic phenotype CTD_human Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. 20134357 2010
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Biomarker phenotype CTD_human Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. 12646302 2003
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human ACTH-induced seizures in an infant with West syndrome. 2554740 1989
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.300 Therapeutic phenotype CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141 2016
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.300 Biomarker phenotype CTD_human Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. 9630518 1998
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker phenotype CTD_human Mitochondrial DNA damage and the involvement of antioxidant defense and repair system in hippocampi of rats with chronic seizures. 20446108 2010
Entrez Id: 7200
Gene Symbol: TRH
TRH 		0.300 Biomarker phenotype CTD_human Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain. 10443546 1999
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.300 Biomarker phenotype CTD_human Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. 19941057 2010
Entrez Id: 3737
Gene Symbol: KCNA2
KCNA2 		0.300 Biomarker phenotype CTD_human De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. 25751627 2015
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5 		0.300 Biomarker phenotype CTD_human Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures. 14996991 2004
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human [A case of Aicardi syndrome with moderate psychomotor retardation]. 2169275 1990
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1 		0.300 Biomarker phenotype CTD_human Mechanisms of morphine enhancement of spontaneous seizure activity. 18042875 2007
Entrez Id: 1268
Gene Symbol: CNR1
CNR1 		0.300 Biomarker phenotype CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810 2003
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.300 Therapeutic phenotype CTD_human Neuroprotective actions of vitamin C related to decreased lipid peroxidation and increased catalase activity in adult rats after pilocarpine-induced seizures. 18096215 2008
Entrez Id: 4842
Gene Symbol: NOS1
NOS1 		0.300 Biomarker phenotype CTD_human 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures. 8749039 1995
Entrez Id: 4852
Gene Symbol: NPY
NPY 		0.300 Therapeutic phenotype CTD_human Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y. 18005069 2007
Entrez Id: 3954
Gene Symbol: LETM1
LETM1 		0.300 Biomarker phenotype CTD_human LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein. 14706454 2004
Entrez Id: 348980
Gene Symbol: HCN1
HCN1 		0.300 Biomarker phenotype CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
Entrez Id: 2247
Gene Symbol: FGF2
FGF2 		0.300 Therapeutic phenotype CTD_human Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. 21269288 2011
Entrez Id: 2572
Gene Symbol: GAD2
GAD2 		0.300 Biomarker phenotype CTD_human Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. 8985701 1996
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Therapeutic phenotype CTD_human Effects of dopamine D3 receptor agonists on pilocarpine-induced limbic seizures in the rat. 7936204 1994
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.300 Therapeutic phenotype CTD_human Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain. 9073163 1997