| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | The hypospadias phenotype was almost identical to that reported for the estrogen receptor α (ERα) knockout confirming that ERα is the predominant receptor for mediating estrogen action during development of the mouse penis. | 31520742 | 2020 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Similar to single nucleotide polymorphism analysis, different ESR1 haplotypes were associated with risk of hypospadias in nonHispanic white and Hispanic subjects. | 25463985 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | For rs6932902 in ESR1 only maternally derived alleles appeared to increase hypospadias risk in offspring. | 23088992 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Neonatal DHT treatment also induced hypospadias in both Esr1(-/-) and Esr1(+/+) mice. | 19864317 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We did not replicate the associations of the SNPs in SRD5A2 and ESR1 with hypospadias. | 20215396 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These findings suggest that the G allele containing variants of ESR1 XbaI and the G allele containing variants of ESR2 2681-4A>G may decrease the risk of hypospadias, whereas the ESR1 C-A haplotype may increase its risk. | 18375409 | 2008 | ||||
|
0.080 | GeneticVariation | disease | LHGDN | Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias. | 18375409 | 2008 | ||||
|
0.080 | AlteredExpression | disease | LHGDN | Expression of estrogen and androgen receptors in children with hypospadias: preliminary report. | 17453687 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We screened 60 boys with hypospadias for mutations in the coding regions of ESR1 and ESR2 genes, by denaturing high-performance liquid chromatography and automated sequence analysis. | 16553027 | 2006 |