Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | GeneticVariation | disease | BEFREE | ESR2 single nucleotide polymorphisms (rs944050; 2681-4A>G) have been associated with an increased risk of hypospadias in previous studies. | 27300571 | 2016 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | We investigated the relationship between hypospadias and 108 ESR1 and 36 ESR2 single nucleotide polymorphisms in 647 cases and 877 population based nonmalformed controls among infants born in selected California counties from 1990 to 2003. | 25463985 | 2015 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | The SNPs in ESR2 and ATF3 were borderline associated with hypospadias [odds ratios 0.9 (95% confidence interval 0.7-1.0) and 1.2 (95% confidence interval 1.0-1.4), respectively] but in the opposite direction compared with earlier publications. | 20215396 | 2010 | ||||
|
0.060 | GeneticVariation | disease | LHGDN | Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias. | 18375409 | 2008 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | These findings suggest that the G allele containing variants of ESR1 XbaI and the G allele containing variants of ESR2 2681-4A>G may decrease the risk of hypospadias, whereas the ESR1 C-A haplotype may increase its risk. | 18375409 | 2008 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | The present study evidences two nonindependent risk factors for hypospadias in the ESR2 gene. | 17579196 | 2007 | ||||
|
0.060 | GeneticVariation | disease | LHGDN | The CA repeat polymorphism in ESR2 is prolonged in hypospadias patients compared to controls (p < 0.05). | 16553027 | 2006 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | The CA repeat polymorphism in ESR2 is prolonged in hypospadias patients compared to controls (p < 0.05). | 16553027 | 2006 |