| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | Another AP-1 superfamily gene, ATF3, could be responsible for some instances of hypospadias in humans. | 29670181 | 2018 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | The SNPs in ESR2 and ATF3 were borderline associated with hypospadias [odds ratios 0.9 (95% confidence interval 0.7-1.0) and 1.2 (95% confidence interval 1.0-1.4), respectively] but in the opposite direction compared with earlier publications. | 20215396 | 2010 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Mastermind-like domain containing 1/chromosome X open reading frame 6 mutation and activating transcription factor 3 variants have been shown to be associated with the incidence of isolated hypospadias. | 19995686 | 2010 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | In addition, ATF3 expression in 1 human fetal penis with and 1 without hypospadias was studied by immunohistochemical analysis. | 18804813 | 2008 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Three common SNPs, spanning a region of about 16 kb in intron 1 of ATF3, are associated with hypospadias. | 18426833 | 2008 | ||||
|
0.370 | GeneticVariation | disease | LHGDN | Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. | 18426833 | 2008 | ||||
|
0.370 | Biomarker | disease | BEFREE | ATF3 is involved in the TGF-beta epithelial-mesenchymal signaling pathway, and its involvement in hypospadias suggests that ATF3 plays a role in development of this anomaly as a result of exposure to estrogenic compounds. | 18001166 | 2007 | ||||
|
0.370 | Biomarker | disease | CTD_human | Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. | 18001166 | 2007 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | Our results indicate that ATF3 is up-regulated in the penile skin tissues of boys with hypospadias, suggesting a role for this transcription factor in the development of this abnormality. | 16306208 | 2005 |