| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. | 27821802 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | The opposite role of p53 in cisplatin-induced apoptosis among TC cell lines demonstrates the importance of the cellular context for the p53 transactivation phenotype in TC cells. | 23165211 | 2012 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Although high levels of wild-type p53 and hardly any TP53 mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patients. | 21509038 | 2011 | ||||
|
0.090 | Biomarker | disease | BEFREE | Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. | 10029060 | 1999 | ||||
|
0.090 | Biomarker | disease | BEFREE | High susceptibility of testicular cancer to drug-induced apoptosis appears to be the result of wild-type p53 and lack of bcl-2. | 9524567 | 1998 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | With two papers confirming the importance of excess p53 expression in determining GCC chemotherapy response, particularly in seminoma, the question of whether seminoma should be treated with different chemotherapy strategies re-emerges. | 9619364 | 1998 | ||||
|
0.090 | Biomarker | disease | BEFREE | Our findings do not indicate that TP53 plays any major pathogenic role in this tumor type, nor was there any indication that defect repair genes, causing microsatellite instability in other cancers, participate in the progression of testicular cancer. | 7474934 | 1995 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | P53 tumor suppressor gene protein immunostaining was evaluated in the primary tumor of adult testicular germ cell cancer to assess if P53 expression would serve as a clinically useful tumor marker. | 8015085 | 1994 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | No germline TP53 mutations detected in familial and bilateral testicular cancer. | 7680893 | 1993 |