Similarly, XJEK treatment for 2 wk potentiated Nrf2 nuclear translocation and HO-1 expression and inhibited the deficiency of nuclear Nrf2 and HO-1 at 6 wk post-MI compared with that of the MI groups, indicating the attenuation of the renal oxidative stress condition.
Then, starting from 7th until 21st day post-MI a more potent deterioration of LV function was observed in Hmox1<sup>-/-</sup> than in the surviving Hmox1<sup>+/+</sup> mice.
In the current study, we assessed the effect of HO-1 gene delivery on post-MI left ventricle (LV) remodeling and function using echocardiographic imaging and histomorphometric approaches.