×
Entrez Id:
2875
Gene Symbol:
GPT
GPT
0.400
Biomarker
phenotype
CTD_human
Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats.
145039
1977
×
Entrez Id:
3440
Gene Symbol:
IFNA2
IFNA2
0.300
Biomarker
phenotype
CTD_human
A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma.
1670585
1991
×
Entrez Id:
3552
Gene Symbol:
IL1A
IL1A
0.320
Therapeutic
phenotype
CTD_human
The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity.
8218930
1993
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.350
Biomarker
phenotype
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385
1995
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.350
Therapeutic
phenotype
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385
1995
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.330
Therapeutic
phenotype
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385
1995
×
Entrez Id:
3875
Gene Symbol:
KRT18
KRT18
0.320
GeneticVariation
phenotype
BEFREE
However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased susceptibility to drug-induced hepatotoxicity .
9011570
1997
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.350
Biomarker
phenotype
CTD_human
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
9696492
1998
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.350
Therapeutic
phenotype
CTD_human
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
9696492
1998
×
Entrez Id:
2944
Gene Symbol:
GSTM1
GSTM1
0.400
GeneticVariation
phenotype
BEFREE
Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation.
11595069
2001
×
Entrez Id:
2946
Gene Symbol:
GSTM2
GSTM2
0.350
GeneticVariation
phenotype
BEFREE
Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation.
11595069
2001
×
Entrez Id:
3627
Gene Symbol:
CXCL10
CXCL10
0.310
Therapeutic
phenotype
CTD_human
IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes.
11739529
2001
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
0.310
Therapeutic
phenotype
CTD_human
These findings suggest that COX-2 -derived mediators serve an important hepato-protective function and that COX inhibition may contribute to the risk of drug-induced liver injury , possibly through both nonimmunological and immunological pathways.
11743745
2001
×
Entrez Id:
3589
Gene Symbol:
IL11
IL11
0.300
Therapeutic
phenotype
CTD_human
Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity.
11421492
2001
×
Entrez Id:
10
Gene Symbol:
NAT2
NAT2
0.400
Biomarker
phenotype
CTD_human
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
11915035
2002
×
Entrez Id:
3458
Gene Symbol:
IFNG
IFNG
0.300
Biomarker
phenotype
CTD_human
A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.
12153990
2002
×
Entrez Id:
6649
Gene Symbol:
SOD3
SOD3
0.300
Therapeutic
phenotype
CTD_human
EC-SOD gene therapy reduces paracetamol-induced liver damage in mice.
11529661
2002
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.400
Biomarker
phenotype
CTD_human
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
12668988
2003
×
Entrez Id:
1557
Gene Symbol:
CYP2C19
CYP2C19
0.320
Biomarker
phenotype
CTD_human
Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene.
12963435
2003
×
Entrez Id:
6652
Gene Symbol:
SORD
SORD
0.300
Biomarker
phenotype
CTD_human
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
12763371
2003
×
Entrez Id:
9971
Gene Symbol:
NR1H4
NR1H4
0.300
Biomarker
phenotype
CTD_human
[Functional analysis of drug metabolizing enzymes using gene knockout animals].
12875239
2003
×
Entrez Id:
4254
Gene Symbol:
KITLG
KITLG
0.200
Therapeutic
phenotype
CTD_mouse
Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury.
12594235
2003
×
Entrez Id:
1559
Gene Symbol:
CYP2C9
CYP2C9
0.320
Biomarker
phenotype
CTD_human
Leflunomide-induced acute hepatitis.
14971821
2004
×
Entrez Id:
9970
Gene Symbol:
NR1I3
NR1I3
0.320
Therapeutic
phenotype
CTD_human
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
14742670
2004
×
Entrez Id:
9970
Gene Symbol:
NR1I3
NR1I3
0.320
Biomarker
phenotype
CTD_human
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
14742670
2004