Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 Biomarker phenotype BEFREE The role of p53 in pathogenesis of drug-induced liver injury is unknown. 29654721 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 GeneticVariation phenotype BEFREE In addition, most of these associations have not been investigated in antituberculosis drug-induced hepatotoxicity (ATDH) patients with the exception of TNF-α polymorphisms. 25308608 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype BEFREE Tumor necrosis factor-α antagonists (anti-TNF-α) have been associated with drug-induced liver injury. 29564668 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype BEFREE Furthermore, LPA administration decreased the production of TNF-α and IL-1β in an experimental drug-induced liver injury animal model. 29217823 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 GeneticVariation phenotype BEFREE IL-10, IL-4 and TNF-alpha genetic polymorphisms were not related to the risk of developing DILI. 18485518 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype BEFREE The uncontrolled production of inflammatory factors including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) in CILI, AILI and DILI models was also suppressed by PNP80b-2. 31712149 2019
Entrez Id: 55151
Gene Symbol: TMEM38B
TMEM38B 		0.300 Biomarker phenotype CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Entrez Id: 84187
Gene Symbol: TMEM164
TMEM164 		0.300 Biomarker phenotype CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Entrez Id: 84216
Gene Symbol: TMEM117
TMEM117 		0.300 Biomarker phenotype CTD_human Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. 26881866 2016
Entrez Id: 51014
Gene Symbol: TMED7
TMED7 		0.300 Biomarker phenotype CTD_human Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. 26881866 2016
Entrez Id: 54106
Gene Symbol: TLR9
TLR9 		0.010 Biomarker phenotype BEFREE Such requirement was further observed in inflammatory models where DNA sensing via TLR9 contributes to disease, such as silicosis and drug-induced liver injury. 31836766 2019
Entrez Id: 7100
Gene Symbol: TLR5
TLR5 		0.300 Biomarker phenotype CTD_human TLR5 silencing reduced hyperammonaemia-induced liver injury by inhibiting oxidative stress and inflammation responses via inactivating NF-κB and MAPK signals. 30508503 2019
Entrez Id: 9392
Gene Symbol: TGFBRAP1
TGFBRAP1 		0.010 GeneticVariation phenotype BEFREE The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury. 31534460 2019