Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.300 Therapeutic phenotype CTD_human Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. 20068143 2010
Entrez Id: 7494
Gene Symbol: XBP1
XBP1 		0.300 Therapeutic phenotype CTD_human XBP1s Is an Anti-lipogenic Protein. 27325692 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Biomarker phenotype CTD_human Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. 19008412 2009
Entrez Id: 5563
Gene Symbol: PRKAA2
PRKAA2 		0.300 Biomarker phenotype CTD_human AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. 19934007 2010
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.300 Biomarker phenotype CTD_human The beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker. 19034036 2008
Entrez Id: 57761
Gene Symbol: TRIB3
TRIB3 		0.300 Biomarker phenotype CTD_human Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans. 20461355 2010
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker phenotype CTD_human Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. 25734695 2015
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1 		0.300 Biomarker phenotype CTD_human AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. 19934007 2010
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4 		0.300 Therapeutic phenotype CTD_human Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus. 11947963 2002
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1 		0.300 Biomarker phenotype CTD_human A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components. 23512162 2013
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.300 Therapeutic phenotype CTD_human Adiponectin upregulates ferritin heavy chain in skeletal muscle cells. 18931039 2009
Entrez Id: 3164
Gene Symbol: NR4A1
NR4A1 		0.300 Biomarker phenotype CTD_human After observing that expression of two NR4A orphan nuclear receptors, NR4A3 and NR4A1, was altered by insulin in cDNA microarray analyses of human skeletal muscle, we studied whether these receptors could modulate insulin sensitivity. 17785466 2007
Entrez Id: 3290
Gene Symbol: HSD11B1
HSD11B1 		0.300 Biomarker phenotype CTD_human Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1. 21786805 2011
Entrez Id: 5465
Gene Symbol: PPARA
PPARA 		0.300 Therapeutic phenotype CTD_human Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. 21324916 2011
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker phenotype CTD_human Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. 29988851 2018
Entrez Id: 5770
Gene Symbol: PTPN1
PTPN1 		0.300 Biomarker phenotype CTD_human Recent studies have shown increased insulin sensitivity and resistance to obesity in PTP1B knockout mice, thus pointing to this enzyme as a potential drug target in diabetes. 10744717 2000
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker phenotype CTD_human Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. 25796170 2015
Entrez Id: 2778
Gene Symbol: GNAS
GNAS 		0.300 Biomarker phenotype CTD_human The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome. 17062894 2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker phenotype CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673 2019
Entrez Id: 5295
Gene Symbol: PIK3R1
PIK3R1 		0.300 Biomarker phenotype CTD_human [Cell biological mechanism involved in the effect of sodium selenite on improving insulin sensitivity]. 14714311 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Biomarker phenotype CTD_human Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. 24150608 2014
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1 		0.300 Biomarker phenotype CTD_human Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. 22658938 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.300 Biomarker phenotype CTD_human CoPP improved glucose tolerance and insulin sensitivity in WT mice on HFD, but compromised insulin sensitivity in Sirt1-deficient mice on HFD. 26026874 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.300 Biomarker phenotype CTD_human Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation. 18303120 2008
Entrez Id: 718
Gene Symbol: C3
C3 		0.300 Biomarker phenotype CTD_human Sex steroid hormones induce acylation stimulating protein resistance in 3T3-L1 adipocytes. 18615583 2008