Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27035
Gene Symbol: NOX1
NOX1 		0.010 Biomarker disease BEFREE NOX1 and DUOX2 may be potential therapeutic targets for treating ileocolitis in human patients suffering inflammatory bowel disease (IBD). 27930931 2017
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 Biomarker disease CTD_human A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. 11385577 2001
Entrez Id: 1672
Gene Symbol: DEFB1
DEFB1 		0.010 AlteredExpression disease BEFREE A functional promoter variant that is required for DEFB1 expression confers strong protection against Crohn's colitis and ileocolitis (odds ratio, 0.559; P = 0.018). 20421464 2010
Entrez Id: 345611
Gene Symbol: IRGM
IRGM 		0.300 Biomarker disease CTD_human A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. 21278745 2011
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 GeneticVariation disease BEFREE Analysis of 229 patients with ileal or ileocolonic disease and a NOD2/CARD15 mutation disclosed that ileocolitis was more prevalent through age 10, while isolated ileitis was more prevalent above age 10 (P = 0.016). 17763471 2007
Entrez Id: 10551
Gene Symbol: AGR2
AGR2 		0.010 Biomarker disease BEFREE Anterior gradient protein 2 homologue (AGR2) assists in maintaining intestinal homeostasis in dextran sulphate sodium-induced mouse ileocolitis; however, it is unclear whether it modulates intestinal barrier function. 28339048 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.300 Biomarker disease CTD_human Antioxidant and immune status in active Crohn's disease. A possible relationship. 10700533 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker disease CTD_human Antioxidant and immune status in active Crohn's disease. A possible relationship. 10700533 2000
Entrez Id: 2358
Gene Symbol: FPR2
FPR2 		0.300 Biomarker disease CTD_human Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production. 21659618 2011
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 Biomarker disease CTD_human Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. 11385576 2001
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 Biomarker disease CTD_human CARD15 mutations in Blau syndrome. 11528384 2001
Entrez Id: 4583
Gene Symbol: MUC2
MUC2 		0.010 AlteredExpression disease BEFREE Casp8<sup>∆IEC</sup> mice developed ileocolitis accompanied by changes in intestinal barrier morphology and reduced expression of barrier-related genes such as mucin-2 (<i>Muc2)</i> and defensins in the ileum and <i>Muc2</i> in the colon. 31411503 2019
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 Biomarker disease CTD_human Cell culture models in developing nutrigenomics foods for inflammatory bowel disease. 17568627 2007
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3 		0.300 Biomarker disease CTD_human Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. 19098911 2009
Entrez Id: 54106
Gene Symbol: TLR9
TLR9 		0.300 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
Entrez Id: 345611
Gene Symbol: IRGM
IRGM 		0.300 Biomarker disease CTD_human Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. 19165925 2008
Entrez Id: 1666
Gene Symbol: DECR1
DECR1 		0.010 AlteredExpression disease BEFREE Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2. 31689440 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.300 Biomarker disease CTD_human Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease. 19751734 2010
Entrez Id: 7448
Gene Symbol: VTN
VTN 		0.300 Biomarker disease CTD_human Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease. 19751734 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1 		0.300 Biomarker disease CTD_human Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease. 19751734 2010
Entrez Id: 9213
Gene Symbol: XPR1
XPR1 		0.010 Biomarker disease BEFREE Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. 28647362 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.310 Biomarker disease BEFREE Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. 28647362 2017
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.330 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
Entrez Id: 4485
Gene Symbol: MST1
MST1 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
Entrez Id: 159296
Gene Symbol: NKX2-3
NKX2-3 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008