Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Due to the controversial data on the neuroprotective properties of metformin, we treated Apolipoprotein E deficient (ApoE- /-) mice, a mouse model of tauopathy, with metformin for 18 weeks. | 30909226 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology. | 30949567 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | Our data imply that increased age and APOE ɛ4 status are risk factors for co-pathologies independent of neurodegenerative disease; that neurodegenerative disease severity influences co-pathology as evidenced by the prevalence of co-pathology in high Alzheimer's disease and neocortical Lewy body disease, but not intermediate Alzheimer's disease or limbic Lewy body disease; and that tau and α-synuclein strains may also modify co-pathologies since tauopathies and synucleinopathies had differing co-pathologies and burdens. | 29878075 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | Our data together suggest APOE ε2 status may influence the risk and progression of tauopathy. | 30348994 | 2018 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Further, the data were most compatible with the hypothesis that the APOEɛ4 allele exerts its effect(s) via driving Aβ deposition, i.e., an "upstream" influence, rather than being associated directly with Aβ- independent PART pathology. | 30040735 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. | 28959956 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | When divided into the 3 subgroups (tauopathies, synucleinopathies, and frontotemporal degeneration), apolipoprotein E epsilon 4 had a similar effect, whereas older age and female sex were less predictive. | 15477512 | 2004 |