Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.700 | Biomarker | disease | CTD_human | Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. | 28696432 | 2018 | ||||
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0.700 | Biomarker | disease | PSYGENET | Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. | 24411473 | 2014 | ||||
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0.700 | Biomarker | disease | PSYGENET | Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. | 24642287 | 2014 | ||||
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0.700 | Biomarker | disease | PSYGENET | Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. | 24262814 | 2014 | ||||
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0.700 | Biomarker | disease | PSYGENET | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 24643163 | 2014 | ||||
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0.700 | Biomarker | disease | PSYGENET | Genetic variation in CACNA1C affects neural processing in major depression. | 24612926 | 2014 |