Gene: NPM1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.050 GeneticVariation disease BEFREE Induction of mutant Npm1 after development of Dnmt3a-mutant CH causes progression to myeloproliferative disorder (MPD), and more aggressive MPD is observed with longer latency between mutations. 30692594 2019
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.050 GeneticVariation disease BEFREE Thus, our mouse model demonstrated that Npm1 mutation can result in MPD, but is insufficient for leukemogenesis. 23226219 2012
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.050 GeneticVariation disease BEFREE The NPM1 mutation induces a myeloproliferative disorder, but evidence indicates that other insults are necessary for the development of AML. 22348345 2012
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.050 GeneticVariation disease BEFREE Thus, NPM1 mutations are involved in the transformation from MDS to AML or MPN to blast phase in single cases, which should be further confirmed in larger studies. 21233837 2011
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.050 GeneticVariation disease BEFREE We determined mutations and promoter methylation status of NPM1 using pyrosequencing in 199 samples of myeloid neoplasia including myeloproliferative disorders (MPD). 16870548 2006