Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET). 29134817 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Chronic myelogenous leukemia (CML) is a chronic myeloproliferative neoplasm characterized by the presence of Philadelphia chromosome [t(9:22)] leading to the presence of pathognomonic fusion gene product, BCR-ABL1. 28988389 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Acquisition of genomic events leading to lymphoblastic transformation in a rare case of myeloproliferative neoplasm with BCR-JAK2 fusion transcript. 26935241 2017
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis frequently harbor JAK2, MPL, and CALR somatic mutations. 28406068 2017
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Identification of BCR-ABL1 tyrosine kinase as a driver of chronic myeloid leukemia (CML) and successful application of small molecule inhibitors of the tyrosine kinases in the clinic have triggered the search for kinase dependent pathways in other Ph-ve MPNs. 26062813 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm underlain by the formation of BCR-ABL1 - an aberrant tyrosine kinase - in the leukaemic blasts. 26439403 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). 26933174 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE TERT rs2736100_C polymorphism predisposes to the development of BCR-ABL1-negative MPN with the co-occurrence of solid tumors, especially with the usage of cytoreductive treatment. 26487696 2016
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE RARS-T is a provisional entity in the MDS/MPN (myeloproliferative neoplasm) overlap syndromes, with diagnostic features of RARS, along with a platelet count ≥450 × 10(9)/L and large atypical megakaryocytes similar to those observed in BCR-ABL1 negative MPN. 25899435 2015
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Current data suggest that constitutively active JAK-STAT signaling plays a central role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasms (MPNs), regardless of the specific underlying molecular abnormality. 25520049 2015
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE To assess the presence of genetic imbalances in patients with myeloproliferative neoplasms (MPNs), 38 patients with chronic eosinophilia were studied by array comparative genomic hybridization (aCGH): seven had chronic myelogenous leukaemia (CML), BCR-ABL1 positive, nine patients had myeloproliferative neoplasia Ph- (MPN-Ph-), three had a myeloid neoplasm associated with a PDGFRA rearrangement, and the remaining two cases were Lymphoproliferative T neoplasms associated with eosinophilia. 24813417 2015
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Polycythaemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (MF), are the most common myeloproliferative neoplasms (MPN) in patients without the BCR-ABL1 gene rearrangement. 23986553 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Novel BCR-ABL1 fusion identified by targeted next-generation sequencing in a patient with an atypical myeloproliferative neoplasm. 24927924 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE In BCR-ABL1-negative myeloproliferative neoplasms (MPNs) several different tyrosine kinase fusion events have been described, most commonly involving the genes encoding the platelet-derived growth factor receptor alpha (PDGFRA) or beta (PDGFRB). 23186533 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The majority of patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) harbor mutations in JAK2 or MPL, which lead to constitutive activation of the JAK/STAT, PI3K and ERK signaling pathways. 23748344 2013
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Immediately after the annual scientific meeting of the American Society of Hematology (ASH), a select group of clinical and laboratory investigators in myeloproliferative neoplasms (MPN) is summoned to a post-ASH conference on chronic myeloid leukemia and the BCR-ABL1-negative MPN. 22460584 2012
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE JAK2V617F is sufficiently prevalent in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) to be useful as a clonal marker. 21723416 2012
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasm (MPN). 22106054 2012
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE JAK-STAT is an appealing but also problematic drug target in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - it is appealing because the majority of patients with MPN harbor gain-of-function JAK2 or MPL mutations - it is problematic because currently available JAK inhibitors do not distinguish between oncogenic and physiologic JAK-STAT activation. 21742423 2011
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Most BCR-ABL1-negative myeloproliferative neoplasms (MPN) carry an activating JAK2 mutation. 21646683 2011
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The discovery of JAK2V617F and other JAK-STAT-activating mutations in BCR-ABL1-negative myeloproliferative neoplasms (MPN) has led to the development of small-molecule ATP-mimetics that inhibit wild-type and mutant JAK. 21245760 2011
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE BCR-ABL1 negative MPN displays myeloproliferation with an elevated leucocyte alkaline phosphatase (LAP) activity, a neutrophil activation marker. 20553273 2010
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Data on angiogenesis in the bone marrow of BCR-ABL1-negative myeloproliferative neoplasm (MPN) patients suggest an increase of the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression, but relations to the JAK2-V617F status remain controversial. 19466975 2009
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence in leukemic stem cells of the Philadelphia chromosome (Ph) and the formation of the BCR-ABL1 fusion. 18767145 2008
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation. 17255768 2007