Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. 26468945 2016
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE Immunophenotypic alterations, either in CD34(+) cells or myelomonocytic cells, were detected in 82 of 83 (99%) MPN cases. 25557358 2016
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Exogenous IL-33 promoted cytokine production and colony formation by primary CD34+ MPN stem/progenitor cells from patients. 26011644 2015
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Treatment of polycythemia vera (PV) and primary myelofibrosis (PMF) CD34(+) cells with low doses of RG7112 and Peg-IFNα 2a before their transplantation into immune-deficient mice decreased the degree of donor-derived chimerism as well as the JAK2V617F allele burden, indicating that these drugs can each alone or in combination deplete MPN HSCs. 24869939 2014
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE Despite its upregulation in MPN CD34+ and during normal erythropoiesis, both overexpression and knockdown studies suggest that miR-433 negatively regulates CD34+ proliferation and differentiation ex vivo. 22864358 2013
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE Using Ba/F3-EPOR cells and ex vivo cultured CD34(+) cells from MPN patients, we demonstrate that expression of JAK2(V617F) affected the p53 response to DNA damage. 21785463 2012
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE To investigate the leukemogenic effect of AML1/RUNX1 mutants, the AML1D171N mutant was transduced into CD34(+) cells from patients in the CP of MPNs. 19850737 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE After directed hematopoietic differentiation, the MPD-iPS cell-derived hematopoietic progenitor (CD34(+)CD45(+)) cells showed the increased erythropoiesis and gene expression of specific genes, recapitulating features of the primary CD34(+) cells of the corresponding patient from whom the iPS cells were derived. 19797525 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Hybridization of genomic DNA from CD34-positive blasts of acute myeloid leukemia (n=19) or myeloproliferative disorder (n=1) with the arrays identified 9148 nonsynonymous nucleotide changes. 20400977 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE JAK2V617F-positive MC colonies were assayable from the PB CD34(+) cells of each of the 17 JAK2V617F positive MPN patients studied. 19387466 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE These studies indicate that adult CD34(+) cells can be affected by JAK2V617F and that they can generate ELC which might play a role in the development of thrombosis in patients with MPN. 19762257 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE Finally, we found that Lnk levels are high in CD34(+) hematopoietic progenitors from MPD patients and that Lnk expression is induced following JAK2 activation. 19293402 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Erythroid cells expanded from primary CD34(+) cells from patients with MPDs were inhibited by lestaurtinib at concentrations of 100 nM or more in 15 of 18 subjects, with concomitant inhibition of phosphorylation of STAT5 and other downstream effectors of JAK2. 17984313 2008