Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | AlteredExpression | disease | BEFREE | Further results revealed that TRPV3 inhibition decreased expressions of p-CaMKII, CyclinA, CyclinD1, CyclinE, and increased P27 level; (4) CONCLUSIONS: Our findings demonstrate that TRPV3 was overexpressed in NSCLC and correlated with lung cancer progression. | 27023518 | 2016 | ||||
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0.070 | AlteredExpression | disease | BEFREE | Functional studies demonstrated that the 13H3 antibody suppressed lung cancer cell lines ANIP-973 and A549 proliferation in vitro and inhibit ANIP973 xenograft tumors growth in vivo by inducing cell-cycle arrest at G1 phase, with up-regulation of p27 and down-regulation of cyclin D1. | 23184915 | 2013 | ||||
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0.070 | AlteredExpression | disease | BEFREE | Vorinostat also reduced cyclin D1 and cyclin E expression, but increased p27 levels in post- versus pretreatment human lung cancer biopsies. | 23686769 | 2013 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | We hypothesize that the inhibition of thromboxane synthase (TXS) induces the death of lung cancer cells and that such inhibition is associated with the nuclear p27 level. | 19576211 | 2009 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | However, the regulation of p27 expression and the role of p27 during lung cancer are poorly understood. | 19648963 | 2009 | ||||
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0.070 | GeneticVariation | disease | BEFREE | When individuals with variant-containing genotypes were compared with homozygous wild-type carriers, a significantly increased lung cancer risk was identified for polymorphisms in p53 intron 6 [rs1625895; odds ratio (OR), 1.29; 95% confidence interval (95% CI), 1.08-1.55] and in p27 5' untranslated region (UTR; rs34330; OR, 1.27; 95% CI, 1.01-1.60). | 17908995 | 2007 | ||||
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0.070 | AlteredExpression | disease | BEFREE | In several tumors including lung cancer, decreased expression of p27 is associated with poor prognosis. | 11165393 | 2001 |