Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		0.030 Biomarker disease BEFREE PI3K inhibitors have the potential to increase radioiodide accumulation in some differentiated thyroid cancer. 18762555 2008
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB 		0.030 Biomarker disease BEFREE PI3K inhibitors have the potential to increase radioiodide accumulation in some differentiated thyroid cancer. 18762555 2008
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.030 Biomarker disease BEFREE PI3K inhibitors have the potential to increase radioiodide accumulation in some differentiated thyroid cancer. 18762555 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.030 Biomarker disease BEFREE PI3K inhibitors have the potential to increase radioiodide accumulation in some differentiated thyroid cancer. 18762555 2008
Entrez Id: 7421
Gene Symbol: VDR
VDR 		0.040 GeneticVariation disease BEFREE Vitamin D receptor polymorphisms in differentiated thyroid carcinoma. 19499989 2009
Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5 		0.100 AlteredExpression disease BEFREE NIS expression was lower in DTC patients over 45 years old and in tumours larger than 2 cm. 21521301 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.030 Biomarker disease BEFREE Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer. 21876975 2011
Entrez Id: 3897
Gene Symbol: L1CAM
L1CAM 		0.010 AlteredExpression disease BEFREE L1CAM expression was not detectable in normal follicular epithelial cells of the thyroid or in differentiated thyroid carcinoma. 22472175 2012
Entrez Id: 7068
Gene Symbol: THRB
THRB 		0.010 AlteredExpression disease BEFREE THRB mRNA expression in DTC was 90% lower than in normal controls, and this decrease was associated with a higher tumor/lymph node staging. 23183175 2013
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1 		0.080 GeneticVariation disease BEFREE XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies. 23717668 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.100 GeneticVariation disease BEFREE BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one. 24468978 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.090 Biomarker disease BEFREE Vascular endothelial growth factor-targeted kinase inhibitors have emerged as highly promising therapies for radioiodine-refractory metastatic differentiated thyroid cancer. 24628546 2014
Entrez Id: 406982
Gene Symbol: MIR20A
MIR20A 		0.010 AlteredExpression disease BEFREE MiR-20a expression was significantly higher in anaplastic thyroid cancer than in differentiated thyroid cancer, and benign and normal thyroid tissues. 24858712 2014
Entrez Id: 7361
Gene Symbol: UGT1A
UGT1A 		0.010 GeneticVariation disease BEFREE UGT1A haplotypes associate with T4 dosage in DTC patients, but the effect accounts for only 2% of the total variability and recommendation of pre-emptive UGT1A genotyping is not warranted. 24910925 2014
Entrez Id: 6513
Gene Symbol: SLC2A1
SLC2A1 		0.010 Biomarker disease BEFREE GLUT1 (SLC2A1) is the most prevalent isoform in more aggressive and less differentiated thyroid cancer histotypes. 25125078 2014
Entrez Id: 4015
Gene Symbol: LOX
LOX 		0.010 Biomarker disease BEFREE LOX was identified as a direct target of miR30a that was overexpressed in ATC and associated with advanced differentiated thyroid cancer and higher mortality rate. 25488748 2015
Entrez Id: 7015
Gene Symbol: TERT
TERT 		0.060 GeneticVariation disease BEFREE TERT C228T is far more common than TERT C250T and their collective prevalence is, on average, 0, 11.3, 17.1, 43.2 and 40.1% in benign thyroid tumors, papillary thyroid cancer (PTC), follicular thyroid cancer, poorly differentiated thyroid cancer and anaplastic thyroid cancer, respectively, displaying an association with aggressive types of thyroid cancer. 26733501 2016
Entrez Id: 110806263
Gene Symbol: LOC110806263
LOC110806263 		0.100 GeneticVariation disease BEFREE TERT Promoter Mutation Predicts Radioiodine-Refractory Character in Distant Metastatic Differentiated Thyroid Cancer. 27493271 2017
Entrez Id: 2304
Gene Symbol: FOXE1
FOXE1 		0.100 GeneticVariation disease BEFREE FOXE1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population. 27610545 2016
Entrez Id: 7038
Gene Symbol: TG
TG 		0.100 AlteredExpression disease BEFREE Thyroglobulin levels measured at the time of remnant ablation to predict response to treatment in differentiated thyroid cancer after thyroid hormone withdrawal or recombinant human TSH. 27655291 2017
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4 		0.010 GeneticVariation disease BEFREE CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid carcinoma. 28326838 2017
Entrez Id: 7038
Gene Symbol: TG
TG 		0.100 Biomarker disease BEFREE Thyroglobulin autoantibodies before radioiodine ablation predict differentiated thyroid cancer outcome. 28467308 2017
Entrez Id: 3956
Gene Symbol: LGALS1
LGALS1 		0.010 AlteredExpression disease BEFREE Galectin-1 (gal-1), a protein overexpressed in well-differentiated thyroid cancer, has been targeted with a randomized linear 12-mer peptide library using the phage display technique. 28986753 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.100 Biomarker disease BEFREE BRAF = B-Raf proto-oncogene, serine/threonine kinase; CI = confidence interval; CT = computed tomography; DTC = differentiated thyroid cancer; FDG = fluorodeoxyglucose; PET = positron emission tomography; PTC = papillary thyroid cancer; SUV = standardized uptake value. 29144823 2018
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.020 Biomarker disease BEFREE Adiponectin was inversely associated with TC risk among women (OR<sub>T3vs.T1</sub>  = 0.69, 95% CI: 0.49-0.98, P<sub>trend</sub>  = 0.04) but not among men (OR<sub>T3vs.T1</sub>  = 1.36, 95% CI: 0.67-2.76, P<sub>trend</sub>  = 0.37). 29168186 2018