| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Finally, forced expression of oncogenic NRAS (NRAS<sup>Q61R</sup>) in thyroid organoids established from p53 knockout mice and transplantation of the manipulated organoids into mouse recipients generated a model of poorly differentiated thyroid cancer. | 29470983 | 2018 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Recently, the introduction of next-generation sequencing techniques led to the identification of TERT promoter and TP53 mutations in DTC. | 27578827 | 2016 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Association of p53 (-16ins-pro) haplotype with the decreased risk of differentiated thyroid carcinoma in Iranian-Azeri patients. | 25410025 | 2015 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer. | 25835179 | 2015 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Murine double minute 2 (MDM2) oncoprotein and p14(ARF) tumor suppressor play pivotal roles in regulating p53 and function in the MAPK pathway, which is mutated frequently in differentiated thyroid carcinoma (DTC). | 23218882 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Because the loss of p53 function is responsible for the progression of well-differentiated thyroid cancer to more aggressive phenotypes, we hypothesized that p73 might also be involved in thyroid carcinogenesis. | 14522906 | 2003 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Anaplastic changes associated with p53 gene mutation in differentiated thyroid carcinoma after insufficient radioactive iodine (131I) therapy. | 11128725 | 2000 | ||||
|
0.090 | Biomarker | disease | BEFREE | Thus, neither p53 nor VHL genes play a significant role in the pathogenesis of differentiated thyroid cancer. | 9360526 | 1997 | ||||
|
0.090 | Biomarker | disease | BEFREE | The findings of this study therefore strongly suggest that p53 may play a role in the regulation of cell proliferation, and in this capacity slow the growth of and be related to the prognosis of differentiated thyroid cancer in children. | 7640449 | 1995 |