Gene: ATM ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 CausalMutation group CLINVAR
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 Biomarker group CTD_human
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group BEFREE The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation. 8665503 1996
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 Biomarker group BEFREE We also studied breast tumors from ATM mutants, and three showed retention of both alleles, whereas the fourth showed loss of the mutant allele. 9537233 1998
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group BEFREE Loss of heterozygosity (LOH) in the ATM region of chromosome 11q23.1 showed that the normal ATM allele was lost in the breast tumor of the older sister. 10571946 1999
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group BEFREE We screened a cohort of 173 nonselected primary breast tumors for LOH in a 4 cM region at 11q23 spanning the ATM gene. 11793440 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. 11805335 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 Biomarker group LHGDN Consortium piecing together role of ATM gene in breast cancer. 11830600 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Dominant negative ATM mutations in breast cancer families. 11830610 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN ATM mutations in Finnish breast cancer patients. 11897822 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls. 11996792 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Re: Dominant negative ATM mutations in breast cancer families. 12072552 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Constitutional alterations of the ATM gene in early onset sporadic breast cancer. 12362033 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Contributions of ATM mutations to familial breast and ovarian cancer. 12810666 2003
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN ATM missense mutations are frequent in patients with breast cancer. 12935922 2003
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families. 15390180 2005
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 PosttranslationalModification group LHGDN These findings indicate that epigenetic silencing of ATM expression occurs in locally advanced breast tumors, and establish a link at the molecular level between reduced ATM function and sporadic breast malignancy. 15516988 2004
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 PosttranslationalModification group BEFREE These findings indicate that epigenetic silencing of ATM expression occurs in locally advanced breast tumors, and establish a link at the molecular level between reduced ATM function and sporadic breast malignancy. 15516988 2004
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 Biomarker group LHGDN Two ATM variants and breast cancer risk. 15880680 2005
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN Cancer risks and mortality in heterozygous ATM mutation carriers. 15928302 2005
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 AlteredExpression group BEFREE Loss of heterozygosity at the ATM locus has been reported in 30-40% of breast tumours and 50-70% show altered ATM protein levels. 16112413 2005
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 AlteredExpression group BEFREE Fifty-two breast tumors from 51 patients, 38 of them with concomitant in situ component (CIS), were analyzed by immunohistochemistry for the expression of ATM. 16329039 2006
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 AlteredExpression group LHGDN Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. 16636671 2006
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. 16652348 2006
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.500 GeneticVariation group LHGDN ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. 16832357 2006