| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | group | BEFREE | Inducible cyclooxgenase-2 (COX-2) is commonly overexpressed in breast tumors and is a target for cancer therapy. | 28666869 | 2017 | ||||
|
0.080 | Biomarker | group | BEFREE | COX-2 modulates mammary tumor progression in response to collagen density. | 27000374 | 2016 | ||||
|
0.080 | AlteredExpression | group | BEFREE | These data suggest that downregulation of RhoGDI could be a critical mechanism of breast tumor development, which may involve the hyperactivation of Rho GTPases and upregulation of COX-2 activity. | 26416248 | 2015 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. | 24590894 | 2014 | ||||
|
0.080 | AlteredExpression | group | BEFREE | By immunocytochemistry, Western blotting and flow cytometry analysis, oestrogen treatment of R2d cells was found to induce many important effects related to breast carcinogenesis, namely: (i) the emergence of a subpopulation of cells expressing CD44+/high/CD24-/low breast tumour stem cell markers; (ii) the induction of EMT (epithelial-to-mesenchymal transition); (iii) the acquisition of metastatic ability; and (iv) the expression of COX-2 (cyclo-oxygenase-2) through a CD44-mediated mechanism. | 19895368 | 2010 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Up-regulation of COX-2 in ER-negative and HER2-positive breast tumors is associated with Akt pathway activation and is a marker of poor outcome. | 21078168 | 2010 | ||||
|
0.080 | AlteredExpression | group | BEFREE | COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. | 17542993 | 2007 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Immunohistochemical analyses of human breast tumor specimens revealed a strong correlation between expression of Cox-2 and MDR1/Pgp170. | 11501838 | 2001 |