Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.380 | CausalMutation | disease | CGI | |||||||
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0.380 | GeneticVariation | disease | BEFREE | ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. | 25427834 | 2015 | ||||
|
0.380 | Biomarker | disease | BEFREE | We developed an animal model of ATRX-deficient GBM and showed that loss of ATRX reduces median survival and increases genetic instability. | 26936505 | 2016 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Combined BRAF and ATRX mutations are rare in gliomas, with only a pediatric case of glioblastoma being reported in the literature. | 28185325 | 2017 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | H3K27M mutation occurs exclusively in pHGGs arising from the midline and presents with varied histomorphological features ranging from low-grade pilomyxoid astrocytoma to highly pleomorphic glioblastoma along with ATRX loss and p53 mutations. | 29063957 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | ATRX-mutated GBMs exhibited statistically significant increased CD3 immunoreactivity, while those with p53 mutations were found to have significantly increased CTLA4 immunoreactivity. | 29302887 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | A new molecular group of GBMs harbored alterations in ATRX or DAXX genes in the absence of driver IDH or H3F3A mutations. | 30010995 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | We describe genetic alterations in isocitrate dehydrogenase, ATRX, the telomerase promoter, and histone H3 variants that promote GBM tumorigenesis and have altered GBM categorization. | 29548052 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. | 29721688 | 2018 |