Gene: CD274 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. 29632728 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE Tumor-associated macrophages from matched GBM tissue had even greater B7-H1 expression. 23613317 2013
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE In contrast, CBD notably decreased in GBM surface levels of PD-L1, a critical immune checkpoint agent for T-lymphocytes. 30783513 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE PD-L1 is commonly expressed on the GBM-infiltrating T cells. 26323609 2016
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE Finally, we demonstrated that PD-L1 overexpression promoted while knockdown abolished GBM development and invasion in orthotopic GBM models of rodents. 29510196 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 Biomarker disease BEFREE Our results indicate that anti-PD-L1 immunotherapy enhances a radiation induced abscopal response via canonical T-cell activation and direct macrophage activation in glioblastoma. 31793634 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE PD-L1 expression on glioblastoma surface promotes PD-1 receptor activation in microglia, resulting in the negative regulation of T cell responses. 31661771 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE Our results suggest that TMZ therapy leads to a down-regulation of PD-L1 in primary GBM cells. 30709339 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 Biomarker disease BEFREE In this review, we describe the immunosuppressive molecular characteristics of the tumour microenvironment (TME), candidate biomarkers of PD-1/PD-L1 checkpoint blockades, ongoing clinical trials and challenges of PD-1/PD-L1 checkpoint blockades in glioblastoma. 30777100 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE The effects of GMCI on PD ligand 1 (PD-L1) expression in glioblastoma were investigated in vitro and in vivo. 29016938 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 Biomarker disease BEFREE We unveiled that GBM-associated MDSCs promoted regulatory B-cell function by delivering microvesicles transporting membrane-bound PD-L1, able to be up-taken by tumoral B cells. 31530559 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 Biomarker disease BEFREE PD-1/PD-L1 immune-checkpoint inhibitors in glioblastoma: A concise review. 30819441 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 Biomarker disease BEFREE PD-L1 may represent a promising biomarker that predicts disease progression in patients with glioma or GBM. 28652622 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.100 AlteredExpression disease BEFREE Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme. 29088776 2017