| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | AlteredExpression | disease | BEFREE | Our data indicate that the impaired circRNA expression of the AKT3 gene contributes to GBM tumorigenesis, and our data corroborate the hypothesis that restoring AKT3-174aa while inhibiting activated AKT may provide more benefits for certain GBM patients. | 31470874 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1. | 31660951 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Moreover, cell differentiation was modulated by c-Myc in kRas/Akt3-induced GBM on the basis of Nestin/GFAP expression (glial progenitor cell differentiation), while Cdc20 had no effect on primary glial progenitor cell differentiation. | 26993778 | 2016 | ||||
|
0.380 | Biomarker | disease | BEFREE | Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells. | 26902608 | 2016 | ||||
|
0.380 | Biomarker | disease | BEFREE | Therefore strategies that inhibit AKT3 may be unhelpful in some GBM patients. | 27422127 | 2016 | ||||
|
0.380 | Biomarker | disease | BEFREE | The present study was designed to examine the inhibitory effect of AKT3, PI3KCA, and VEGFR2 small interfering RNAs (siRNAs) on GBM cell invasiveness. | 25501707 | 2015 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Knockdown of AKT3 and PI3KCA by RNA interference changes the expression of the genes that are related to apoptosis and autophagy in T98G glioblastoma multiforme cells. | 26481529 | 2015 | ||||
|
0.380 | Biomarker | disease | BEFREE | The present study was designed to examine the inhibitory effect of AKT3 or PI3KCA siRNAs on GBM cell growth, viability, and proliferation.T98G cells were transfected with AKT3 and/or PI3KCA siRNAs. | 24967401 | 2014 | ||||
|
0.380 | GeneticVariation | disease | UNIPROT |