Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. 10477433 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease CLINVAR E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. 10477433 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE More recently, germline E-cadherin/CDH1 mutations have been identified in hereditary diffuse gastric cancer kindred. 10593993 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease CLINVAR Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. 10037790 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 Biomarker disease CTD_human We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. 10433926 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 Biomarker disease CLINGEN We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online. 10094558 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE These results demonstrate that germline mutation of the E-cadherin gene is a common cause of hereditary diffuse gastric cancer and suggest a role for these mutations in the incidence of breast cancer. 10477433 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases. 10389930 1999
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.300 Biomarker disease CTD_human Decrease in nucleophosmin/B23 mRNA and telomerase activity during indomethacin-induced apoptosis of gastric KATO-III cancer cells. 10619186 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. 10404093 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 PosttranslationalModification disease BEFREE Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. 10973239 2000
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. 10973239 2000
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma. 11104024 2000
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.400 Biomarker disease CTD_human DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene. 10874023 2000
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.310 GeneticVariation disease BEFREE There were no FGC cases that showed germline CHK2 mutations. 11011113 2000
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker disease CTD_human Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. 10853026 2000
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.040 PosttranslationalModification disease BEFREE Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. 10585582 2000
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE E-cadherin gene mutations in association with familial gastric cancer is a new disease for which prophylactic surgery must be considered. 11602891 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE We recommend genetic counseling and consideration of prophylactic gastrectomy in young, asymptomatic carriers of germ-line truncating CDH1 mutations who belong to families with highly penetrant hereditary diffuse gastric cancer. 11419427 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 CausalMutation disease CLINVAR Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. 11419427 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.800 GeneticVariation disease BEFREE Breast and colorectal cancer have also been reported in CDH1-associated HDGC. 11729114 2001