Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.400 AlteredExpression disease BEFREE (4) The expression levels of IL-6, IL-10, and TNF-α in peripheral blood were significantly increased after severe sepsis (P < 0.01). 30112606 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 AlteredExpression disease BEFREE (4) The expression levels of IL-6, IL-10, and TNF-α in peripheral blood were significantly increased after severe sepsis (P < 0.01). 30112606 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 Biomarker disease BEFREE -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. 8832971 1997
Entrez Id: 284697
Gene Symbol: BTBD8
BTBD8 		0.070 Biomarker disease BEFREE 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. 29352162 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.050 GeneticVariation disease BEFREE 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. 20429897 2010
Entrez Id: 5187
Gene Symbol: PER1
PER1 		0.010 GeneticVariation disease BEFREE Severe sepsis (P = 0.03), bladder and intravascular catheters (both P = 0.01), immunosuppressive therapy (P = 0.04), and mechanical ventilation (P = 0.03) were significantly associated with BSI due to PER-1-Pa. Empirical treatment (P = 0.02) and treatment after ID/AST (P < 0.01) were rarely adequate in PER-1-Pa cases. 16542460 2006
Entrez Id: 5091
Gene Symbol: PC
PC 		0.010 Biomarker disease BEFREE Severe sepsis is associated with an exacerbated procoagulant state with protein C (PC) system impairment. 17673691 2007
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN 		0.040 GeneticVariation disease BEFREE Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. 11876758 2002
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.010 GeneticVariation disease BEFREE APOE polymorphism is associated with risk of severe sepsis in surgical patients. 16276176 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.100 GeneticVariation disease BEFREE IL-6 174 G/C, FVL, and Cathepsin G (Ars 125 Ser) did not influence the incidence and mortality of severe sepsis. 16444434 2006
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.020 GeneticVariation disease BEFREE ACE I/D polymorphism was not associated with severe sepsis susceptibility or mortality. 18060663 2008
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.400 Biomarker disease BEFREE Activated protein C (APC) reduces mortality in severe sepsis patients. 19244160 2009
Entrez Id: 2149
Gene Symbol: F2R
F2R 		0.020 Biomarker disease BEFREE Protease activated receptor-1 (PAR1) mediates barrier protective signalling of activated protein C (APC) in human endothelial cells in vitro and may contribute to APC's beneficial effects in patients with severe sepsis. 19350118 2009
Entrez Id: 2973
Gene Symbol: GTS
GTS 		0.010 AlteredExpression disease BEFREE GTS-21 decreased TNF levels in endotoxin-stimulated whole blood obtained from patients with severe sepsis. 19593403 2009
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.400 Biomarker disease BEFREE Activated protein C (APC) inhibits inflammation and apoptosis in monocytes, and this may partly explain the protective effects of APC treatment in severe sepsis. 21166994 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		0.030 AlteredExpression disease BEFREE Bcl-2 gene expression was less (P < 0.0001) and Bim gene expression was greater (P = 0.0003) in severe sepsis compared to bacteraemic and healthy controls. 21711552 2011
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.030 AlteredExpression disease BEFREE Heme oxygenase 1 plasma levels were determined in additional patients with severe sepsis (n = 92) by enzyme-linked immunosorbent assay. 23042203 2012
Entrez Id: 10544
Gene Symbol: PROCR
PROCR 		0.030 GeneticVariation disease BEFREE Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients. 23881209 2013
Entrez Id: 629
Gene Symbol: CFB
CFB 		0.010 Biomarker disease BEFREE Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. 24154627 2013
Entrez Id: 213
Gene Symbol: ALB
ALB 		0.070 AlteredExpression disease BEFREE Serum albumin levels were measured, and laboratory and clinical data were collected at the onset of severe sepsis. 28013574 2018
Entrez Id: 5806
Gene Symbol: PTX3
PTX3 		0.020 Biomarker disease BEFREE Pentraxin 3 (PTX3) has been suggested to be a prognostic marker of mortality in severe sepsis. 28120568 2017
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1 		0.320 Biomarker disease BEFREE ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. 28901393 2017
Entrez Id: 7108
Gene Symbol: TM7SF2
TM7SF2 		0.010 Biomarker disease BEFREE ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. 28901393 2017
Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2 		0.030 AlteredExpression disease BEFREE ANG2 was the only gene whose expression was significantly increased in patients developing severe sepsis than in those with uncomplicated sepsis. 29413717 2018
Entrez Id: 738
Gene Symbol: VPS51
VPS51 		0.010 AlteredExpression disease BEFREE ANG2 was the only gene whose expression was significantly increased in patients developing severe sepsis than in those with uncomplicated sepsis. 29413717 2018