Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently added to chemotherapy in the treatment of colon cancer.
Evaluation of epidermal growth factor receptor (EGFR) gene amplification by fluorescence <i>in situ</i> hybridization was subsequently performed in 74 ADCC samples.