Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2244
Gene Symbol: FGB
FGB
0.010 GeneticVariation phenotype BEFREE FGB -455G>A polymorphism and -148C>T polymorphism were not significantly associated with susceptibility to VTE in overall populations. 31770277 2019
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.010 Biomarker phenotype BEFREE We performed a retrospective study of CRS/HIPEC procedures at our institution from 8/2007 to 11/2017, examining the 60-day VTE incidence. 31065960 2019
Entrez Id: 1356
Gene Symbol: CP
CP
0.010 Biomarker phenotype BEFREE We assessed associations between CP and venous thromboembolism (VTE) risk in 9933 individuals. 30803124 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.010 AlteredExpression phenotype BEFREE Chemokine C-C motif ligand 3 (CCL3) levels were inversely associated with risk of VTE (hazard ratio [HR] per double increase, 95% confidence interval [CI]: 0.385, 95% CI: 0.161-0.925, <i>p =</i> 0.033), while there was no association between the risk of VTE and serum levels of interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-11, tumor necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF), respectively. 31847343 2019
Entrez Id: 7290
Gene Symbol: HIRA
HIRA
0.010 GeneticVariation phenotype BEFREE Throughout the study period, 24 patients (4.4%) in the KMM151 cohort and 80 patients (5.1%) in the HIRA cohort developed VTE. 30291558 2019
Entrez Id: 407037
Gene Symbol: MIR320A
MIR320A
0.010 AlteredExpression phenotype BEFREE Moreover, an over-expression of miR-320a/b, miR-582, miR-195, miR-424-5p, and miR-532, or a down-regulation of miR495, miR-136-5p and miR-26a may improve the accuracy of VTE diagnosis. 30903874 2019
Entrez Id: 929
Gene Symbol: CD14
CD14
0.010 Biomarker phenotype BEFREE Monocyte subsets were assessed 12 (8.5-21.5) months after VTE using flow cytometry and were defined as classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14+CD16++). 30088349 2019
Entrez Id: 151056
Gene Symbol: PLB1
PLB1
0.010 Biomarker phenotype BEFREE We describe a patient diagnosed with anti-phospholipase A2 receptor antibody positive membranous nephropathy and recurrent VTE while on therapeutic dosing of apixaban. 30421320 2019
Entrez Id: 24145
Gene Symbol: PANX1
PANX1
0.010 Biomarker phenotype BEFREE BrilliantBlue-FCF, a Panx1 channel inhibitor, decreased collagen-induced platelet aggregation in vitro, increased tail bleeding time and reduced VTE in wild-type mice. 31669824 2019
Entrez Id: 55840
Gene Symbol: EAF2
EAF2
0.010 GeneticVariation phenotype BEFREE Mendelian randomization analyses were conducted for traits genetically associated with novel VTE loci. 31420334 2019
Entrez Id: 406941
Gene Symbol: MIR149
MIR149
0.010 Biomarker phenotype BEFREE This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. 30637557 2019
Entrez Id: 574501
Gene Symbol: MIR499A
MIR499A
0.010 Biomarker phenotype BEFREE This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. 30637557 2019
Entrez Id: 2319
Gene Symbol: FLOT2
FLOT2
0.010 GeneticVariation phenotype BEFREE Eur J Anaesthesiol 2018; 35:73-76.A synopsis of all recommendations can be found in the following accompanying article: Afshari A, Ageno W, Ahmed A, et al., for the ESA VTE Guidelines Task Force. 28901992 2018
Entrez Id: 8350
Gene Symbol: H3C1
H3C1
0.010 Biomarker phenotype BEFREE Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. 29325226 2018
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.010 Biomarker phenotype BEFREE The system revealed a strong new signal with dipeptidylpeptidase-4 inhibitors and venous thromboembolism. 29185236 2018
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
0.010 GeneticVariation phenotype BEFREE Patients diagnosed with VTE based on contrast-enhanced CT during hospitalizations between May 1, 2009 and April 30, 2017 were analyzed. 29872303 2018
Entrez Id: 8942
Gene Symbol: KYNU
KYNU
0.010 AlteredExpression phenotype BEFREE Of the 8 genes tested in the in silico gene expression analyses, KYNU (p < 0.001), CCBL1 (p < 0.001), and CCBL2 (p = 0.001) were significantly different between VTE and N-VTE, controlling for age and sex. 29544199 2018
Entrez Id: 4810
Gene Symbol: NHS
NHS
0.010 GeneticVariation phenotype BEFREE Adult BMI was strongly associated with VTE in all three cohorts (e.g., multivariable-adjusted HRs comparing ≥35 kg/m<sup>2</sup> vs. <22.5 kg/m<sup>2</sup>: NHS:3.03[95% CI: 2.58, 3.56], NHS II:3.82[95% CI: 3.24, 4.51], HPFS:2.81 [95% CI: 2.08, 3.80]; all p-trends < 0.01). 30384037 2018
Entrez Id: 55248
Gene Symbol: PACC1
PACC1
0.010 Biomarker phenotype BEFREE Delegation of the prescribing of VTE prophylaxis for high risk surgical patients to a pharmacist prescriber in PAC, as part of a designated scope of practice, would result in fewer cases of VTE and associated lower costs to the healthcare system and increased QALYs gained by patients. 30285744 2018
Entrez Id: 8353
Gene Symbol: H3C6
H3C6
0.010 Biomarker phenotype BEFREE Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. 29325226 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.010 GeneticVariation phenotype BEFREE In this retrospective study of 173 individuals with a diagnosis of either colorectal, pancreatic, or ovarian Cancer, higher tumor marker levels (CEA, CA 19-9, and CA 125 respectively) were associated with an increased risk of VTE, either DVT or PE. 28470575 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.010 Biomarker phenotype BEFREE COPD is a well-known risk factor for venous thromboembolism (VTE) development. 29593386 2018
Entrez Id: 2821
Gene Symbol: GPI
GPI
0.010 GeneticVariation phenotype BEFREE In a cross-sectional case-control study, cases were (a) 57 consecutive patients (male/female [M/F] 33/24, mean age 57 [10] years) attending a thrombosis unit for ARE (myocardial infarction [MI] n = 20, peripheral vascular disease n = 7, and ischemic strokes n = 30); (b) 52 consecutive patients (M/F 22/30, mean age 55 [17] years) attending the same unit for unprovoked (VTE); (c) normal controls comprised 90 participants (M/F 35/55, mean age 41 [15] years); and (d) oxLDL/β<sub>2</sub>GPI complexes were measured by immunoassay and resulting levels divided into quartiles. 29669439 2018
Entrez Id: 2512
Gene Symbol: FTL
FTL
0.010 Biomarker phenotype BEFREE The risk of VTE increased by categories of higher RDW and was strengthened after inclusion of hepcidin and FtL in the multivariable model. 29844204 2018
Entrez Id: 5493
Gene Symbol: PPL
PPL
0.010 Biomarker phenotype BEFREE Incorporation of Procoag-PPL and MRI of thrombin generation may improve the accuracy of a VTE-RAM in the above setting. 30104289 2018