Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease LHGDN Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia. 31285539 2020
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease UNIPROT
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE High FLT3 expression and IL10 (G1082A) polymorphism in poor overall survival in calla acute lymphoblastic leukemia. 23086275 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease LHGDN Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. 15044257 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. 24067137 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE FLT3 mutations in canine acute lymphocytic leukemia. 21272320 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease LHGDN FLT3 mutations in childhood acute lymphoblastic leukemia. 14670924 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE The present study employed single cell mutation analysis to evaluate the FLT3-ITD status in newly diagnosed acute myeloid leukemia (n = 5) and acute lymphocytic leukemia (n = 3) patients. 24495871 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.800 GeneticVariation disease BEFREE Two of 25 ALL patients (8%) showed a mutated band of FLT3-ITD mutation representing 12.5% of pediatric patients, and all the other ALL cases showed the absence of this mutation. 24390456 2014
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease GWASDB Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. 19684604 2009
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE The impact of IKZF1 deletion on the prognosis of acute lymphoblastic leukemia: an updated meta-analysis. 25335741 2014
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE PAX5 deletions are frequent in adult BCR-ABL1-positive acute lymphoblastic leukemia and are not associated with a poor outcome. 20534699 2010
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients. 27979924 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Ikaros (IKZF1) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ABL-negative acute lymphoblastic leukemia. 22997141 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions. 27229714 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia. 30511400 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia. 24435167 2014
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. 26202931 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease GWASCAT GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. 29348612 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis. 25012940 2015
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. 29507076 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia. 30877974 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL. 27957801 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable. 23585525 2013