Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 Biomarker disease BEFREE Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. 28994305 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions. 27229714 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia. 30511400 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia. 24435167 2014
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. 26202931 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 Biomarker disease BEFREE Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. 19129520 2009
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis. 25012940 2015
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. 29507076 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia. 30877974 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL. 27957801 2017
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 Biomarker disease BEFREE Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. 21606506 2011
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable. 23585525 2013
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 Biomarker disease BEFREE Arrest of differentiation was observed in PAX5-PML-introduced pro-B cells, resulting in the development of acute lymphoblastic leukemia after a long latency in mice. 26703467 2016
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia. 21549623 2011
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 AlteredExpression disease BEFREE Relative PAX5 mRNA levels were significantly increased in B-ALL patients (p<0.0001). 21813177 2012
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan. 23930217 2013
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 Biomarker disease BEFREE Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. 24939936 2014
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 Biomarker disease BEFREE PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. 30643249 2019
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 AlteredExpression disease BEFREE IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia. 27157479 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan. 21740479 2011
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. 19770381 2009
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE In addition, PAX5 deletion was observed in 60% of B-ALL with 9p alterations. 20160164 2010
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. 30842609 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.700 GeneticVariation disease BEFREE A novel PAX5 rearrangement in TCF3-PBX1 acute lymphoblastic leukemia: a case report. 30563523 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.700 GeneticVariation disease BEFREE An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions. 24064621 2014