|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because of this, A3G-D128K expression in HIV-1 target cells is a potential anti-HIV gene therapy approach that could be combined with other therapies for the treatment and functional cure of HIV-1 infection.
|
31778955 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G (A3G) is a cellular protein that inhibits HIV-1 infection through virion incorporation.
|
31165049 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
The host antiviral protein APOBEC3G (A3G) antagonizes the early steps of HIV-1 infection through the combined effects of inhibiting viral cDNA production and cytidine-to-uridine-driven hypermutation of this cDNA.
|
29158605 |
2018 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (<i>Macaca leonina</i>).
|
30210504 |
2018 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the current study was to evaluate any correlation of APOBEC3G genetic variation rs8177832 with HIV-1 infection.
|
30338740 |
2018 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings report genetic variants possibly associated with susceptibility to HIV-1 infection (CUL5 rs11212495, rs7103534, rs7117111) and partial viral load control (APOBEC3G rs2294367).
|
28302043 |
2017 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-encoded vif protein antagonizes such restriction by targeting APOBEC3G for degradation.
|
28098260 |
2017 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, latent HCMV infection downregulated the expression of HIV-1 restriction factors SAMHD1, APOBEC3G, tetherin, and Mx2 in CD34<sup>+</sup> progenitor cells, which may confer to enhanced HIV-1 infection.
|
29296946 |
2017 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, a total of 483 HIV-1 seropositive men and 493 HIV-1 seronegative men were selected to investigate the association between single nucleotide polymorphisms (SNPs) of the APOBEC3G gene and susceptibility to HIV-1 infection and AIDS progression among MSM residing in northern China.
|
27730383 |
2017 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso.
|
26741797 |
2016 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pokeweed antiviral protein restores levels of cellular APOBEC3G during HIV-1 infection by depurinating Vif mRNA.
|
26275799 |
2015 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection.
|
24418556 |
2014 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytidine deaminase APOBEC3G (A3G) exerts a multifaceted antiviral effect against HIV-1 infection.
|
22301159 |
2012 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since the Brazilian population is a mix of Portuguese, native Amerindians, and Africans we aimed to explore the influence of A3G polymorphisms in HIV-1 infection in this heterogeneous host population.
|
20874421 |
2011 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.
|
19996938 |
2010 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because the functions of Vif and APOBEC3G/F proteins oppose each other, it is likely that fluctuations in the Vif-APOBEC balance may influence the natural history of HIV-1 infection, as well as viral sequence diversification and evolution.
|
19038776 |
2009 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report a detailed examination of human APOBEC3 gene expression, focusing on APOBEC3G (A3G) and APOBEC3F (A3F), which are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) infection but are suppressed by HIV-1 Vif.
|
19587057 |
2009 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, pseudotyped HIV-1 infection and cytokine/chemokine-enriched supernatants from lipopolysaccharide-stimulated macrophage cultures induced APOBEC3G expression in NT2-N cells.
|
19027180 |
2009 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
In resting CD4 T cells, a LMM form of A3G potently restricts HIV-1 infection soon after virion entry.
|
19008196 |
2009 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results clearly reveal that expression of R88-A3G in transduced CD4(+) C8166 cells significantly blocked Vif(+) HIV-1 infection.
|
18414671 |
2008 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we demonstrated that no genetic H186R polymorphism in exon 4 of APOBEC3G gene is found and therefore neither associated with differential susceptibility to HIV-1 infection/progression among North Indians.
|
18652534 |
2008 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this pilot study, we tested whether APOBEC3G, when it is fused with UBA2, can resist Vif-mediated proteasomal degradation and further inhibit HIV-1 infection.
|
18680593 |
2008 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, CD14highCD16- monocytes contained low molecular mass active APOBEC3G, suggesting this is a mechanism of resistance to HIV-1 infection in these cells.
|
17475889 |
2007 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that there might be a role for APOBEC3G in susceptibility to HIV-1 infection that warrants further investigation.
|
16988524 |
2006 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner.
|
16039909 |
2005 |