We explored the effects of G-CSF on vascular endothelium and white matter (WM) injury in cerebral small vessel disease(CSVD) via the model of spontaneously hypertensive rat(SHR) so as to elucidate the mechanism of G-CSF on vascular cognitive impairment(VCI).
Thus, this study investigated the preventive effects and mechanisms of action associated with granulocyte colony-stimulating factor (G-CSF) on cognitive dysfunction in elderly diabetic mice with cerebral small vessel disease.
We investigated whether G-CSF exerted positive effects on BBB protection and cognitive function improvement in spontaneously hypertensive rats (SHRs), a rat model displaying the early histopathological changes of CSVD.