Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | GeneticVariation | disease | BEFREE | In prostate adenocarcinoma, besides mutations in BRCA1 and BRCA2 genes that are known to increase the incidence of high-risk cancer in young patients, new studies have shown mutation in other gene such as HOXB13 and also polymorphisms in MYC, MSMB, KLK2 and KLK3 that can be related to hereditary prostate cancer. | 27819754 | 2017 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer. | 26289772 | 2016 | ||||
|
0.360 | SusceptibilityMutation | disease | ORPHANET | Prostate cancer: germline prediction for a commonly variable malignancy. | 22974436 | 2012 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | To examine the possibility that germ-line BRCA1 mutations were associated with hereditary prostate cancer, individuals from 93 families with evidence of linkage to chromosome 17q were screened for germ-line BRCA1 mutations. | 15447980 | 2004 | ||||
|
0.360 | SusceptibilityMutation | disease | ORPHANET | Cancer Incidence in BRCA1 mutation carriers. | 12237281 | 2002 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Blood DNA from affected individuals in 38 prostate cancer clusters was analyzed for germ-line mutations in BRCA1 and BRCA2 to assess the contribution of each of these genes to familial prostate cancer. | 10969800 | 2000 | ||||
|
0.360 | Biomarker | disease | BEFREE | Thus, BRCA1 and BRCA2 appear to have a limited role in familial prostate cancer, and families with both prostate and breast cancer may result from mutations in other predisposition genes. | 10728701 | 2000 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | No evidence for a role of BRCA1 or BRCA2 mutations in Ashkenazi Jewish families with hereditary prostate cancer. | 10344217 | 1999 |