| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause of vascular cognitive impairment. | 30232327 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Although the association between apolipoprotein E (APOE) genotype and disease progression is well characterized in patients with Alzheimer's disease, such a relationship is unknown in patients with subcortical vascular cognitive impairment. | 28507298 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | APOE4 is significantly associated with dementia and CIND due to AD pathology, but not with VCI. | 26923016 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We previously conducted a systematic review and meta-analysis of all published genetic association studies of sporadic VCI prior to 6 July 2012, which demonstrated that APOE (ɛ4, ɛ2) and MTHFR (rs1801133) variants were associated with susceptibility for VCI. | 27314523 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. | 23769398 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | This systematic study of all published genetic association studies of sporadic VCI supports MTHFR and APOE as susceptibility genes for VCI. | 23186985 | 2013 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Lower BCRT scores conferred an increased risk of both VCI (OR, 1.75; CI, 1.27-2.42) and AD (OR, 1.86; CI, 1.29-2.67) but attenuated the APOE epsilon4 effect in AD. | 16166776 | 2005 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | In contrast, ApoE epsilon4 allele-bearing individuals had greater risk of having late-onset AD (OR = 8.8; 95% CI 3.7-21.0), or non-vascular cognitive impairment (OR = 7.0; 95% CI 2.5-19.0). | 10362893 | 1999 |