| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Additionally, causal relationships have been found between errors in regulation of SQSTM1/p62 and the development of a variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. | 30657305 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The multifunctional protein p62 is associated with neuropathological inclusions in several neurodegenerative disorders, including frontotemporal lobar degeneration, amyotrophic lateral sclerosis and Alzheimer's disease (AD). | 27573878 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | p62/SQSTM1 analysis in frontotemporal lobar degeneration. | 25433461 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. | 24899140 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72. | 24252525 | 2013 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. | 22972638 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Here we immunoprecipitated endogenous p62 in the cerebral cortex from patients with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and found that p62 coimmunoprecipitated several proteins, including TDP-43, which is a major disease protein in FTLD-TDP. | 22674379 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Neuropathological examination in six cases with C9ORF72 mutation from the frontotemporal lobar degeneration series identified histomorphological features consistent with either type A or B TAR DNA-binding protein-43 deposition; however, p62-positive (in excess of TAR DNA-binding protein-43 positive) neuronal cytoplasmic inclusions in hippocampus and cerebellum were a consistent feature of these cases, in contrast to the similar frequency of p62 and TAR DNA-binding protein-43 deposition in 53 control cases with frontotemporal lobar degeneration-TAR DNA-binding protein. | 22366791 | 2012 |