Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.010 Biomarker disease BEFREE <i>STAT3/PIAS3</i> Levels Serve as "Early Signature" Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube. 29339537 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease BEFREE High-grade serous carcinoma is associated with TP53 mutations, whereas low-grade serous carcinomas are associated with BRAF and KRAS mutations. 26892153 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.030 GeneticVariation disease BEFREE High-grade serous carcinoma is associated with TP53 mutations, whereas low-grade serous carcinomas are associated with BRAF and KRAS mutations. 26892153 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.020 GeneticVariation disease BEFREE High-grade serous carcinoma is associated with TP53 mutations, whereas low-grade serous carcinomas are associated with BRAF and KRAS mutations. 26892153 2016
Entrez Id: 442909
Gene Symbol: MIR342
MIR342 		0.010 AlteredExpression disease BEFREE High-grade serous carcinoma effusions (n=148) were analyzed for expression of miR-29a, miR-31, miR-99b, miR-182, miR-210, miR-221, miR-222, miR-224, and miR-342 using quantitative polymerase chain reaction. 27063471 2016
Entrez Id: 2627
Gene Symbol: GATA6
GATA6 		0.010 Biomarker disease BEFREE High grade serous carcinoma showed a higher percentage of GATA6 positive staining. 30633927 2019
Entrez Id: 387
Gene Symbol: RHOA
RHOA 		0.010 Biomarker disease BEFREE RHOA may cause resistance of high-grade serous carcinoma to chemotherapy. 21208644 2011
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 GeneticVariation disease BEFREE BRCA1 disruptions were associated with the C2 (immunoreactive) molecular subtype of HGSC, characterized by intense intratumoral T-cell infiltration. 23633455 2013
Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A 		0.010 Biomarker disease BEFREE TOP2A protein was also found elevated in human STICs, low-grade and high-grade serous carcinoma. 24652535 2014
Entrez Id: 1994
Gene Symbol: ELAVL1
ELAVL1 		0.010 AlteredExpression disease BEFREE HUR mRNA expression in ovarian high-grade serous carcinoma effusions is associated with poor survival. 26640230 2016
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.010 AlteredExpression disease BEFREE MDM2 expression was significantly higher in clear cell carcinoma than in ovarian high-grade serous carcinoma (P = 0.0092) and normal tissues (P = 0.035). 27659536 2016
Entrez Id: 55240
Gene Symbol: STEAP3
STEAP3 		0.010 Biomarker disease BEFREE TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma. 27825812 2017
Entrez Id: 5337
Gene Symbol: PLD1
PLD1 		0.010 AlteredExpression disease BEFREE PLD1 and PLD2 isoform expression was studied in 125 HGSC specimens (73 effusions, 28 ovarian tumors, 24 solid metastases) using quantitative real-time reverse-transcription polymerase chain reaction. 28087476 2017
Entrez Id: 6790
Gene Symbol: AURKA
AURKA 		0.010 Biomarker disease BEFREE AURKA and PD-L1 correlated with the resistance to platinum-based chemotherapy in CCC patients (P = 0.043, 0.028, respectively) while no similar results were observed in HGSC patients. 28187748 2017
Entrez Id: 11047
Gene Symbol: ADRM1
ADRM1 		0.010 AlteredExpression disease BEFREE ADRM1 mRNA was quantified by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC). 28784174 2017
Entrez Id: 694
Gene Symbol: BTG1
BTG1 		0.010 AlteredExpression disease BEFREE BTG1 protein expression in ovarian high-grade serous carcinoma tissue samples was evaluated using immunohistochemistry. 28928854 2017
Entrez Id: 1264
Gene Symbol: CNN1
CNN1 		0.010 AlteredExpression disease BEFREE CNN1 was progressively downregulated in cells and tissues representing different stages of HGSC development from fallopian tube epithelium (FTE). 28977852 2017
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1 		0.020 AlteredExpression disease BEFREE CCNE1 expression in high grade serous carcinoma does not correlate with chemoresistance. 28977941 2017
Entrez Id: 2590
Gene Symbol: GALNT2
GALNT2 		0.010 AlteredExpression disease BEFREE GALNT2 displayed significantly lower expression, while GALNT6, GALNT9 and GALNT14 showed significantly higher expression in HGSC tumors compared to control tissue. 29039611 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 Biomarker disease BEFREE TP53 mutation is almost invariably present in HGSC, and p53 immunostaining can be used as a surrogate marker of TP53 mutation. 29187446 2017
Entrez Id: 51079
Gene Symbol: NDUFA13
NDUFA13 		0.010 AlteredExpression disease BEFREE GRIM-19, NF-κB and IKK2 expression was evaluated by immunohistochemistry (IHC) in 71 patients with HGSC selected between 2003 and 2013, whose underwent primary debulking surgery with complete cytoreduction. 29254797 2018
Entrez Id: 9476
Gene Symbol: NAPSA
NAPSA 		0.010 Biomarker disease BEFREE Napsin A and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma. 29266433 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 Biomarker disease BEFREE BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma. 29465507 2018
Entrez Id: 1111
Gene Symbol: CHEK1
CHEK1 		0.010 AlteredExpression disease BEFREE CHK1 and CHK2 and their activated forms are frequently expressed in HGSC effusions, with higher expression following exposure to chemotherapy, and their expression is related to survival. 29804637 2018
Entrez Id: 91039
Gene Symbol: DPP9
DPP9 		0.010 AlteredExpression disease BEFREE DPP9 mRNA was additionally overexpressed in HGSC compared to other histotypes (p = 0.021). 30467600 2019