| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.050 | AlteredExpression | disease | BEFREE | Topical anti-inflammatory effect of CdE (0.001-1mg/ear) and rutin (0.003-0.03mg/ear) was evaluated by ear edema formation and inflammatory cells infiltration (MPO activity and histology) on a skin inflammation model induced by topical application of croton oil (1mg/ear). | 31785385 | 2020 | ||||
|
0.050 | AlteredExpression | disease | BEFREE | The positive controls also prevented both ear edema and the increased of MPO activity by 100% and 42 ± 8% (HC-030031), 54 ± 6% and 80 ± 4% (SB-366791), 100% and 54 ± 5% (indomethacin), 100% and 80 ± 4% (dexamethasone in skin inflammation model induced by phenol) and 100% and 97 ± 3% (dexamethasone in inflammation model induced by croton oil), respectively. | 30445106 | 2019 | ||||
|
0.050 | Biomarker | disease | BEFREE | Pruritus was assessed by the number of scratching bouts, whilst skin inflammation was evaluated by the extravascular accumulation of intravenously injected <sup>125</sup>I-albumin (plasma extravasation) and myeloperoxidase (MPO) activity (neutrophil recruitment). | 27840098 | 2017 | ||||
|
0.050 | AlteredExpression | disease | BEFREE | In the present study, anti-inflammatory and antioxidant mechanisms of systemic administration with trans-chalcone, a flavonoid precursor, on ultraviolet (UV) irradiation-induced skin inflammation and oxidative stress in hairless mice were investigated by the following parameters: skin edema, myeloperoxidase activity (neutrophil marker), matrix metalloproteinase-9 activity, reduced glutathione levels, catalase activity, lipid peroxidation products, superoxide anion production, gp<sup>91phox</sup> (NADPH oxidase subunit) mRNA expression by quantitative PCR and cytokine production by ELISA. | 28594010 | 2017 | ||||
|
0.050 | AlteredExpression | disease | BEFREE | Acetate administration in psoriatic mice led to further increase in skin inflammation (ear thickness/myeloperoxidase activity) with concurrent increase in Th17 immune responses and epidermal dual oxidase-2 signaling. | 28212864 | 2017 |