Niclosamide exerted no significant effects on β-catenin expression and the activities of ERK1/2 and Akt in A10 cells.Injection (i.p.) of soluble pegylated niclosamide (PEG5000-niclosamide) (equivalent to niclosamide 25 mg·kg<sup>-1</sup> ) attenuated neointimal hyperplasia following balloon-injury in rat carotid arteries in vivo.
Our findings implicate MsrA as a negative regulator of vascular smooth muscle cell proliferation and neointimal hyperplasia after vascular injury through control of the Ras/Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 signaling pathway.