Gene: WFS1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease CTD_human Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease. 24705017 2014
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease BEFREE We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress. 20160352 2010
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease MGD Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder. 18343518 2008
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Congenital cataracts in two siblings with Wolfram syndrome. 21067485 2010
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1. 26435059 2015
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Molecular diagnostic experience of whole-exome sequencing in adult patients. 26633545 2016
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease BEFREE The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders. 12605098 2003
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease MGD Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. 15056606 2004
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease MGD Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene. 21031341 2011
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease MGD Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. 19293327 2009
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease BEFREE DNA analysis to examine single-nucleotide polymorphisms in 2 candidate modifier genes (ATP2B2 and Wolfram syndrome 1 [WFS1]) is summarized in this report. 18667942 2008
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Wolfram syndrome: new mutations, different phenotype. 22238590 2012
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease CLINVAR Wolfram syndrome in the Japanese population; molecular analysis of WFS1 gene and characterization of clinical features. 25211237 2014
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease GENOMICS_ENGLAND Correction: Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease. 30171196 2018
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease UNIPROT Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. 9817917 1998
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease UNIPROT Identification of novel WFS1 mutations in Italian children with Wolfram syndrome. 11295831 2001
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Phenotypic characteristics of early Wolfram syndrome. 23981289 2013
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Evidence of an increased risk of hearing loss in heterozygous carriers in a Wolfram syndrome family. 9856492 1998
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease MGD Energy metabolism and thyroid function of mice with deleted wolframin (Wfs1) gene. 24710642 2014
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 CausalMutation disease CLINVAR Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. 18040659 2008
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease UNIPROT Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease. 22226368 2012
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease UNIPROT Wolfram syndrome in French population: characterization of novel mutations and polymorphisms in the WFS1 gene. 15605410 2005
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 Biomarker disease GENOMICS_ENGLAND A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY). 27185633 2016
Entrez Id: 7466
Gene Symbol: WFS1
WFS1 		0.980 GeneticVariation disease UNIPROT Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. 10521293 1999