Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731
COX1 P00395 cytochrome c oxidase subunit I Enzyme 0.441 0.885
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885
DCC P43146 DCC netrin 1 receptor 0.99 0.471 0.808
BCL10 O95999 BCL10 immune signaling adaptor 0.34 0.491 0.769
CYTB P00156 cytochrome b 0.529 0.808
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885
FLCN Q8NFG4 folliculin 0.79 0.537 0.885
FANCC Q00597 FA complementation group C 2.8E-13 0.507 0.808
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962