Disease: Somatic mutation
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808
FOXO1 Q12778 forkhead box O1 1.00 0.433 0.846
TSC2 P49815 TSC complex subunit 2 Enzyme modulator 1.00 0.439 0.808
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846
FLT3 P36888 fms related receptor tyrosine kinase 3 Kinase 0.61 0.462 0.654
NPM1 P06748 nucleophosmin 1 Chaperone 1.00 0.464 0.846
ETV6 P41212 ETS variant transcription factor 6 Transcription factor 0.97 0.477 0.731
CEBPA P49715 CCAAT enhancer binding protein alpha Transcription factor 0.55 0.496 0.692
GATA2 P23769 GATA binding protein 2 0.98 0.496 0.654
NSD1 Q96L73 nuclear receptor binding SET domain protein 1 Epigenetic regulator 1.00 0.505 0.769
LPP Q93052 LIM domain containing preferred translocation partner in lipoma Enzyme modulator 7.2E-03 0.543 0.769
MLLT10 P55197 MLLT10 histone lysine methyltransferase DOT1L cofactor Transcription factor 1.00 0.551 0.462
PICALM Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 1.00 0.592 0.538