Disease: Hypercholesterolemia, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
CFH P08603 complement factor H 0.86 0.441 0.885
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
FGF23 Q9GZV9 fibroblast growth factor 23 Signaling 3.1E-02 0.460 0.731
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923
GPT P24298 glutamic--pyruvic transaminase Enzyme 3.6E-19 0.403 0.923
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962
IL6 P05231 interleukin 6 0.32 0.248 0.962
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
PRKCSH P14314 protein kinase C substrate 80K-H Enzyme 1.0E-07 0.674 0.538
REN P00797 renin Enzyme 2.4E-07 0.370 0.923
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962